Protective efect of silymarin on tacrolimus-induced kidney and liver toxicity

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dc.authoridhttps://orcid.org/0000-0002-6184-5408en_US
dc.contributor.authorTerzi, Funda
dc.contributor.authorÇiftçi, Mustafa Kemal
dc.date.accessioned2023-11-07T16:27:20Z
dc.date.available2023-11-07T16:27:20Z
dc.date.issued2022en_US
dc.departmentDiş Hekimliği Fakültesien_US
dc.description.abstractBackground: Tacrolimus (FK506) is an immunosuppressive agent and has toxic side efects such as nephrotoxicity, hepatotoxicity, and neurotoxicity. In our study, we aimed to investigate the protective efect of silymarin on renal and hepatic toxicity considered to be tacrolimus related. Methods: In this 6-week experimental study, 46 eight-week-old healthy male rats were used. The groups comprised the Control (healthy rats, n=6), Tac (tacrolimus 1 mg/kg, n=8), silymarin 100 mg/kg (SLI 100 mg/kg n=8), Tac+SLI 100 (tacrolimus 1 mg/kg+SLI 100 n=8), SLI 200 (SLI 200 mg/kg n=8), and Tac+SLI 200 (tacrolimus 1 mg/kg+SLI 200 mg/kg n=8). After 6 weeks, all rats were sacrifced, and the tissue follow-up procedure was performed for kidney and liver tissues, histopathology, and in situ TUNEL analysis. Blood samples were analyzed for the total antioxidant capacity (TAC), total oxidant capacity (TOC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), albumin, total bilirubin, creatine. Results: Histopathological fndings of kidney and liver tissue of rats were determined to increase statistically in Tac group compared to SLI 1 00 and SLI 200 groups (P<0.05). In addition, the Tac+SLI 100 and Tac+SLI 200 groups were found to be statistically similar to the Control group (P>0.05). The in situ TUNEL method showed that the tacrolimus increased apoptosis while the silymarin decreased it. TOC levels increased statistically in Tac groups compared to silymarin-treated groups (P<0.05). Although the TAC level was not statistically signifcant among the experimental groups (P>0.05), the lowest was measured in the Tac group. The ALT, AST, GGT, total bilirubin, and creatine values were higher in the Tac group than in the silymarin groups (P<0.05). There was no statistically signifcant diference between the groups with regard to the albumin level (P>0.05). Conclusion: In our study, we determined that tacrolimus caused damage to kidney and liver tissue. Histopathological, biochemical and apoptotic fndings show that silymarin has a protective efect against nephrotoxicity and hepatotoxicity caused by tacrolimus.en_US
dc.identifier.doi10.1186/s12906-022-03803-xen_US
dc.identifier.endpage10en_US
dc.identifier.issn2662-7671
dc.identifier.issue1en_US
dc.identifier.pmid36514062en_US
dc.identifier.scopus2-s2.0-85144108769en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11363/6269
dc.identifier.urihttps://doi.org/
dc.identifier.volume22en_US
dc.identifier.wosWOS:000898788700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇiftçi, Mustafa Kemal
dc.language.isoenen_US
dc.publisherBMC, CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLANDen_US
dc.relation.ispartofBMC Complementary Medicine and Therapiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectSilymarinen_US
dc.subjectTacrolimusen_US
dc.subjectNephrotoxicityen_US
dc.subjectHepatotoxicityen_US
dc.subjectHistopathologyen_US
dc.subjectTUNELen_US
dc.subjectRaten_US
dc.titleProtective efect of silymarin on tacrolimus-induced kidney and liver toxicityen_US
dc.typeArticleen_US

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