DSpace Arşivi :: Ana Sayfa

İstanbul Gelişim Üniversitesi Kurumsal Açık Erişim Arşivi

DSpace@Gelişim, İstanbul Gelişim Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.

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Methane-Fueled Gas Turbine with Hydrogen Blending and Integrated Steam Rankine Cycle, Absorption Refrigeration Cycle, PEM Electrolyzer, and a CO2 Separation Unit
(Elsevier Ltd, 2026) Abouzied, Amr S.; Abed Balla, Hyder H.; Alkhatib, Omar J.; Abokhalil, Ahmed G.; Dahari, Mahidzal; Ahmed, M. A.; Bayhan, Zahra; Alrasheed, Dhaffaf Saud; Fouad, Yasser; Mahariq, Ibrahim
This research introduces and optimizes a novel multi-generation power system integrating a steam Rankine cycle (SRC), a gas turbine (GT), an absorption refrigeration cycle (ARC), a proton exchange membrane (PEM) electrolyzer, and a CO2 separation unit. This system is designed to improve energy efficiency while simultaneously capturing CO2 and producing hydrogen through electrolysis. Two configurations—with and without ARC—are evaluated using a genetic algorithm-based multi-objective optimization framework, which considers exergetic efficiency, CO2 emission reduction, and total cost rate. The findings demonstrate that the proposed system improves exergetic efficiency by up to 71% and reduces CO2 emissions by up to 3.9% compared to a standalone GT system. Furthermore, the system without ARC achieves higher hydrogen production, while the system with ARC provides valuable cooling. These findings demonstrate the feasibility and environmental advantages of integrated power, CO2 capture, and H2 blending systems for sustainable energy generation.
Robust Differential Spiral EIS Co-Design for Bladder Cancer Urine Sensing with Measured-Data Validation
(Elsevier Ltd, 2026) Deif, Mohanad A.; Elhaty, Ismail A.; Hafez, Mohamed A.; Khishe, Mohammad
This paper presents a robust co-design framework for differential spiral electrical impedance spectroscopy (EIS) biosensors, developed as an in silico methodological study for urine-sensing applications in bladder cancer surveillance. The objective is to improve parameter identifiability in label-free differential urine sensing when nuisance effects, fabrication tolerances, and reference mismatch reduce estimation reliability. The framework combines differential sensing to suppress shared common-mode nuisance with joint optimization of sensor geometry and frequency selection. The design is formulated as a minimax Fisher-information problem to improve worst-case identifiability. The primary co-design evaluation uses an application-motivated synthetic protocol with matched budgets and multiple baselines. The proposed method improves worst-case identifiability and Cramér–Rao lowerbound proxy metrics at the same frequency budget, with consistent gains under budget variation, uncertainty amplification, and reference mismatch. To examine transfer beyond the synthetic model family at component level, we additionally analyzed an independent measured EIS dataset using grouped hold-out validation and training-only empirical minimax frequency selection. At a four-frequency budget, the measured-data analysis achieved a balanced accuracy of 79.6% ± 11.6%, compared with 70.4% ± 14.0% for log-uniform selection and 74.1% ± 8.5% for the full 101-frequency spectrum. This independent analysis supports the differential sparsefrequency design principle outside the synthetic generator, but it does not validate the optimized spiral geometry, urine sensing, bladder-cancer diagnosis, or clinical readiness.
Numerical and Bifurcation Analysis with Sensitivity Assessment of a Deterministic Leptospirosis Hantavirus Co-Infection Model
(Wilmington Scientific Publisher, 2026) Ullah, Naeem; Pimpunchat, Busayamas; Shah, Kamal; Abdeljawad, Thabet
In this paper, a deterministic compartmental model is developed in order to study the dynamics of the transmission of leptospirosis and hantavirus co-infection with particular emphasis on the human population. The model includes compartments of susceptible individuals, singly infected classes, co-infected individuals, and recovered individuals, as well as important pathogen exposure and disease progression mechanisms. Analytical features of the proposed model are addressed, such as positivity, boundedness, the existence of equilibrium points, and bifurcation analysis. The next-generation matrix approach is used to obtain the dominant transmission threshold, denoted by, Rc 0 which determine the qualitative behavior of the system. The transmission-free equilibrium of the model is locally asymptotically stable when Rc 0 < 1 and unstable when Rc 0 > 1, indicating disease persistence in the population. In addition, bifurcation analysis is carried out to examine the system behavior near the critical threshold. The analysis confirm the occurrence of a backward transcritical bifurcation. The validity of the analytical results is confirmed through numerical simulations. In particular, the roles of transmission rates, recovery rates, and co-infection dynamics are studied in detail. Sensitivity analysis shows that parameters associated with infection transmission and recovery have the strongest influence on disease burden, with co-infection outcomes being especially responsive to changes in recovery rates. The results indicate that improving treatment efficiency and limiting transmission pathways can reduce both single infections and co-infection occurrences. Overall, this study highlights the importance of targeted control strategies for leptospirosis hantavirus co-infection and emphasizes the need for effective intervention measures to reduce public health risks.
نقش حمایت از کشاورزی در رشد اقتصادی کشورهای عضو سازمان همکاری و توسعهٔ اقتصادی؛ تحلیل پانلی پویا از منظر مدل اقتصاد ملی
(University of Tehran, 2027) Doğan, Emrah; Akbay, Hatice; Alihodžić, Almir
در این مطالعه، از رویکرد داده‌های پانلی پویا و مجموعه داده‌های جامع دربارهٔ کشورهای عضو سازمان همکاری و توسعهٔ اقتصادی (OECD) از سال ۲۰۰۰ تا ۲۰۲۱م استفاده شد تا تأثیر حمایت از کشاورزی بر رشد اقتصادی بررسی شود. با توجه به آثار تأخیری رشد اقتصادی، در این تحلیل بر تأثیر بلندمدت و پایدار اقدام‌های حمایت از کشاورزی تأکید شده است. یافته‌ها نشان می‌دهد که یارانه‌های کشاورزی بر رشد اقتصادی تأثیر مثبت و به‌لحاظ آماری، معناداری دارد. برپایهٔ نتایج، حمایت عمومی از بخش کشاورزی نه‌تنها تولید بخشی را افزایش می‌دهد، بلکه ابزار سیاستی مهمی برای تحریک فعالیت و رشد کلی اقتصادی است. این یافته‌ها با مدل اقتصادی ملی (NEM) باش (۲۰۱۸) همسو بود. بر پایهٔ این یافته‌ها، در چارچوب رشد تولیدمحور، بخش کشاورزی بخشی راهبردی است و تقویت پایدار تولید داخلی، رشد درآمد و تقاضای داخلی از طریق حمایت عمومی را به‌دنبال خواهد داشت. بنابراین، تأثیر فزایندهٔ حمایت از کشاورزی بر رشد درآمد ملی تأیید می‌شود و اهمیت مشارکت فعال دولت در فرایند تولید در تقویت رشد اقتصادی برجسته می‌نماید. شواهد تجربی نشان می‌دهد که سیاست‌های کشاورزی باید در راهبردهای جامع رشد گنجانده شود.
Nano Route, DFT, MEP, and SAR of Pyran-Functionalized Pyrimidinone Hybrids as Potent Larvicides Against Culex Pipiens; Biochemical and Antioxidant Assessments
(Elsevier B.V., 2027) Farag, Basant; Abdel-Haleem, Mohamed; Chinnam, Sampath; Elhaty, Ismail A.; Abozeid, Shaimaa; Gad, Mohammed E.; Saeed, Aamer; Selim, Abdelfattah; Baz, Mohamed M.
In this study, the starting material of the pyran-functionalized pyrimidinone scaffold was synthesized using nanoscience-based techniques. Larvicidal screening was conducted on 3rd larvae of Culex pipiens, the primary vector of West Nile virus according to standard protocols at various concentration levels. Among the synthesized library, derivative 11 emerged as the most potent candidate, displaying the strongest insecticidal power with the lowest LC50 values of 103.19 µg/mL after 24 h and 76.29 µg/mL after 48 h, as well as LC90 values of 248.92 µg/ mL after 24 h and 195.75 µg/mL after 48 h. Biochemical assays revealed that larvae treated with the most potent derivative, 11, showed a notable decrease in important enzymatic activity in comparison to the control. Specifically, the most potent derivative, 11, inhibited AChE activity by approximately 50% and significantly suppressed both α- and β-esterase levels at the LC50 concentration. The study found that treated larvae showed major decreases in both protease and phosphatase digestive enzymes, which resulted in metabolic and digestive process disruptions. The assays revealed that whereas antioxidant enzyme activity declined, lipid peroxidation and total protein carbonyl content increased, which indicated severe oxidative stress and cell damage. The synthesized compounds exhibited promising antioxidant activity, with compound 11 showing the highest radical scavenging potential among the tested derivatives (IC₅₀ = 4.30 µg/mL), approaching the activity of the reference standard ascorbic acid (IC₅₀ = 3.98 µg/mL). Computational DFT studies showed that the synthesized derivatives have moderate electronic stability, with compound 11 displaying the smallest HOMO-LUMO gap and highest softness. The most reactive sites were identified by Fukui, MEP, and Mulliken studies. According to findings, the synthesized compounds are promising bioactive candidates for developing effective multiple roles.