DSpace Arşivi :: Ana Sayfa

İstanbul Gelişim Üniversitesi Kurumsal Açık Erişim Arşivi

DSpace@Gelişim, İstanbul Gelişim Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.

WoS Yayınları

Scopus Yayınları

TR-Dizin Yayınları

PubMed Yayınları

Makaleler

Kitaplar

Bildiriler

Tezler

Güncel Gönderiler

Ignored by the boss: a moderated-mediation study of boss phubbing
(Frontiers Research Foundation, 2026) Balkaş, Jale; Taş, Mehmet; Günsel, Ayşe; Bozkurt, Serdar; Konakay, Gönül; Aksu, Bumin Çağatay
Introduction: This study investigates the workplace implications of boss phubbing (BP)—a managerial behavior in which supervisors prioritize smartphone use over face-to-face interactions with employees. Drawing on Expectancy Violation Theory (EVT), Social Exchange Theory (SET), and Leader– Member Exchange (LMX), BP is conceptualized as a negative relational signal that can undermine employees’ job attitudes. Methods: A moderated mediation model was tested to examine whether satisfaction with supervision (JDI) mediates the relationship between BP and job satisfaction, and whether power distance moderates the direct and indirect effects. Survey data were collected from 412 full-time employees and analyzed using PROCESS Model 7 with bootstrapping. Results and discussion: BP significantly reduced satisfaction with supervision (JDI), which in turn fully mediated its effect on job satisfaction; the direct effect of BP on job satisfaction was not significant. Power distance did not moderate the direct path from BP to satisfaction with supervision (JDI) but did moderate the indirect effect, which was stronger for employees low in power distance. Together, these findings indicate that boss phubbing operates primarily through relational exchange processes and that cultural value orientations shape the extent to which inattentive leadership undermines employees’ job attitudes. These results contribute to the growing literature on digital workplace behaviors by clarifying how, and under what conditions, boss phubbing erodes employee outcomes.
Fasted-State Aerobic Exercise Enhances Cognition and Hippocampal BDNF Signaling in an Alzheimer’s Disease Rat Model
(Plenum Press, 2025) Kırkbir, Fatih; Atasoy, Taner; Khodadadai, Davar; Sajedi, Heidar; Keskin, Özlem; Babaie, Mohammad
Alzheimer’s disease (AD) is a multifactorial disorder that demands a comprehensive management strategy. Both aerobic exercise training and intermittent fasting (IF) have been shown to ameliorate AD symptoms, yet the impact of exercise in the fasted state remains understudied. This study compared the effects of four weeks of moderate intensity treadmill running in either a fasted or a normal fed state on cognitive function and hippocampal BDNF signaling in an amyloid-β (Aβ)1–42-injected rat model of AD. Twenty month old male Wistar rats were allocated into five groups (n=12 each): AD, AD plus IF (ADIF), AD plus exercise training (ADET), AD plus IF plus exercise training (ADIFET), and control. AD was induced by bilateral intra hippocampal Aβ1–42 injection. Exercise interventions (fasted or fed) were conducted 5 days/week for 4 weeks. Aβ injection significantly impaired learning and memory and reduced hippocampal levels of PKA, CREB, and BDNF (p< 0.001). Both fasting and exercise independently elevated plasma and hippocampal β-hydroxybutyrate (βHB) (p< 0.001), with the highest βHB increase observed in the fasted-exercise group (p< 0.01). All intervention groups (ADIF, ADET, and ADIFET) demonstrated significant improvements in cognitive performance and hippocampal levels of PKA, CREB, and BDNF (p< 0.001). The combined fasting plus exercise group produced greater benefits than either IF or exercise alone (p< 0.05), and exercise alone outperformed fasting alone (p< 0.05). These findings indicate that aerobic exercise in the fasted state offers superior neuroprotective and cognitive benefits, likely via upregulation of βHB/PKA/ CREB/BDNF signaling, highlighting fasted state exercise as a promising therapeutic approach for AD.
Future of dental education: digitalization, career outlook, and perspectives of dental students and early-career dentists
(BioMed Central Ltd, 2025) Gavgalı, Yasin Batuhan; Kavaz, Tuğçe
Background This study aims to assess the opinions of dental students and postgraduate dental practitioners in Turkey regarding the digitalisation of dentistry and the future career outlook of the profession. It focuses on understanding participants’ views on digital competence, the integration of digital technologies into dental education, and their intentions related to practising abroad. Methods A cross-sectional questionnaire study was conducted among undergraduate students (4th- and 5th-year) and postgraduate trainees (PhD and specialty students). The survey explored perceptions of digitalisation in dentistry, professional expectations, and factors influencing career decisions. Descriptive statistics were used for data summarisation. Data were collected between September 2023 and June 2024. Statistical significance was set at p< 0.05. Results The required sample size was calculated as 376, and data collection was completed with 378 participants after excluding incomplete or invalid submissions. Participants who were new to the profession or had recently begun postgraduate training reported predominantly theoretical knowledge and hands-on exposure with digital applications in dentistry. Additionally, a significant association was found between responses to two questions examining intentions to practise abroad with or without economic considerations (p=0.001), suggesting that financial factors alone do not fully explain the desire to work internationally. Conclusions Participants perceived a decline in the social prestige of dentistry in recent years, and many expressed hesitations about recommending the profession to close relatives. Although some showed interest in practising abroad, their motivations extended beyond financial concerns, indicating that professional satisfaction, educational conditions, and perceived occupational value also contribute to these intentions.
Comparative gastric microbiota profiles in non-ulcer dyspepsia and peptic ulcer patients
(BioMed Central Ltd, 2025) Polat Sarı, Silva; Soylu, Aliye; Peker, Kıvanç Derya; Adaşi Gökhan; Akgül, Özer; Sapmaz, Burcu; Öner, Yaşar Ali; Yüksel Mayda, Pelin; Çalışkan, Reyhan
Background Recent evidence suggests that the human stomach hosts a diverse microbiota beyond Helicobacter pylori, and that shifts in microbial composition may influence gastric health. In particular, oral-origin bacteria may dominate the gastric niche in the absence of H. pylori, yet their specific roles in different gastroduodenal disorders remain unclear. This study aimed to profile and compare the gastric microbiota composition in Turkish patients with non-ulcer dyspepsia (NUD) and peptic ulcer disease (PUD), in order to better understand microbial profiles potentially associated with gastroduodenal disease. Methods Ninety-eight patients underwent endoscopic evaluation and were divided into two groups according to the presence or absence of ulcers. Group 1 (n=52) included individuals with NUD, while Group 2 (n=46) comprised patients with PUD. Gastric biopsy samples from both groups were analyzed for the relative abundance of H. pylori using quantitative real-time PCR (qPCR), and next-generation sequencing was employed for a comprehensive analysis of the gastric microbiota. Results In total, H. pylori DNA was detected in 71.4% (70/98) of the samples, with a significantly higher prevalence in PUD patients (82.6%) compared to NUD patients (61.5%) (p=0.02). Distinct microbial profiles were observed based on H. pylori status. In NUD patients, Alloprevotella showed significantly higher relative abundance in H. pylorinegative samples (p< 0.05). Among PUD patients, the absence of H. pylori was associated with increased levels of Porphyromonas and Neisseria compared to NUD patients without H. pylori (p< 0.05). These genera, typically associated with the oral cavity, appeared to expand opportunistically when H. pylori was absent. Conclusions The absence of H. pylori in gastric disorders was linked to a notable shift in microbiota composition, with increased representation of oral-origin bacteria such as Alloprevotella, Porphyromonas, and Neisseria. These findings, observed in a Turkish patient cohort, may reflect a potentially compensatory or opportunistic microbial shift in H. pylori-negative gastroduodenal disease. As exploratory findings, this study represents the first analysis from Türkiye comparing gastric microbiota profiles in NUD and PUD patients and provides novel regional insight into gastric microbial ecology.
Association of GSTM1, GSTT1, and TP53 Genetic Variants with Obesity in Children
(AVES, 2025) Dirican, Onur; Buluş, Ayşe Derya; Husseini, Abbas Ali; Hanilçe, Yücel; Oğuztütün, Serpil
Objective: This study explores whether GSTM1, GSTT1, and TP53 rs1042522 polymorphisms, key regulators of detoxification and oxidative stress responses, influence obesity risk and related metabolic profiles in children. Materials and Methods: Blood samples from 60 obese children and 60 healthy controls were analyzed. GSTM1 and GSTT1 deletions were assessed via polymerase chain reaction melting curve analysis, and TP53 rs1042522 was genotyped by direct DNA sequencing. Deviations from Hardy–Weinberg expectations and genotype frequencies in controls were evaluated, and the association of genetic variants with obesity, clinical complications, and metabolic parameters was examined. Results: In obese children, GSTM1 and GSTT1 genotype frequencies deviated from Hardy– Weinberg expectations and differed from controls, whereas TP53 rs1042522 conformed to expected distributions yet was statistically underpowered. The GSTM1 null genotype increased obesity risk 3.28-fold (95% CI: 1.36-7.93, P < .05). The GSTT1 null genotype conferred a 4.76-fold higher risk (95% CI: 2.08-10.88, P < .001). TP53 rs1042522 showed no association (OR = 1.12, 95% CI: 0.44-2.87). The GSTM1 null carriers had elevated cholesterol, low-density lipoprotein (LDL), and gamma-glutamyl transferase, while TP53 Arg/Arg and Pro/Pro carriers exhibited higher LDL and alanine aminotransferase, respectively. No significant links were observed with insulin resistance or hepatic steatosis. Conclusion: The GSTM1 and GSTT1 null genotypes are significant genetic risk factors for childhood obesity, likely through reduced detoxification capacity and subsequent oxidative stress–related metabolic disruption. These findings highlight the importance of considering detoxification pathways when assessing genetic predisposition to obesity in children.