Potential Antiinflammatory Effect of Fungal Polysaccharide Extract from Leucoagaricus leucothites via Activating P38/ERK Phosphorylation in BV-2 Cells

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dc.authoridÅ?EKER KARATOPRAK, GÖKÇE/0000-0001-5829-6914
dc.authoriddumlupınar, berrak/0000-0002-0898-3043
dc.authoridSEKER KARATOPRAK, GOKCE/0000-0001-5829-6914
dc.contributor.authorAltinsoy, Berrak D.
dc.contributor.authorKaratoprak, Gokce S.
dc.date.accessioned2024-09-11T19:53:40Z
dc.date.available2024-09-11T19:53:40Z
dc.date.issued2018
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractThis study aimed to investigate some biological activities and antiinflammatory potential of polysaccharide isolated from Leucoagaricus leucothites in LPS-activated BV-2 cells. Here, we investigated the antioxidant and antimicrobial potential of polysaccharide extract of L. leucothites (LLP) and the effect of LLP on lipopolysaccharide (LPS)-induced inflammatory response and the underlying molecular mechanisms in BV-2 cells. Chemical analysis of LLP were determined by high-performance liquid chromatography (HPLC). Cytotoxicity and productions of TNF-alpha and IL-6 were determined by ELISA. In addition, intracellular mitogen-activated protein kinase (MAPK) signaling pathway was analyzed by Western blot and cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS) expression were measured by real time-PCR. LLP inhibited LPS-stimulated IL-6 and TNF-alpha. In addition, the inhibitory action of LLP not only suppressed COX-2 and iNOS, but also inhibited the activation of p38/ERK MAPKs. Our data suggested that LLP exhibit anti-inflammatory activity that might contribute to the prevention of chronic inflammatory diseases.en_US
dc.identifier.endpage887en_US
dc.identifier.issn0326-2383
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85047428163en_US
dc.identifier.startpage880en_US
dc.identifier.urihttps://hdl.handle.net/11363/8164
dc.identifier.volume37en_US
dc.identifier.wosWOS:000435656900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectanti-inflammatory activityen_US
dc.subjectCOX-2en_US
dc.subjectcytokinesen_US
dc.subjectiNOSen_US
dc.subjectMAPKen_US
dc.titlePotential Antiinflammatory Effect of Fungal Polysaccharide Extract from Leucoagaricus leucothites via Activating P38/ERK Phosphorylation in BV-2 Cellsen_US
dc.typeArticleen_US

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