The effects of lipoic acid on rat submandibular salivary gland in valproic acid induced oxidative stress

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dc.authoridhttps://orcid.org/0000-0001-5122-4977
dc.contributor.authorAlev Tüzüner, Burçin
dc.contributor.authorTürkyılmaz Mutlu, İsmet Burcu
dc.contributor.authorİpekçi, Hazal
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorTunalı Akbay, Tuğba
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorAkyüz, Serap
dc.contributor.authorYanardağ, Refiye
dc.contributor.authorYarat, Ayşen
dc.contributor.authorAhmad, Sarfraz
dc.date.accessioned2025-07-07T07:06:55Z
dc.date.available2025-07-07T07:06:55Z
dc.date.issued2025
dc.departmentDiş Hekimliği Fakültesi
dc.description.abstractValproic acid (VA), an anticonvulsant drug, has been associated with various toxic effects, primarily through the induction of oxidative stress. This study aimed to investigate the potential protective role of alpha lipoic acid (LA), a potent antioxidant, against VA-induced oxidative damage in rat submandibular salivary glands. Control, LA, VA, and VA+LA are groups. LA was given 1 h prior to VA administration. After 16 days VA injection, the rats were decapitated, and submandibular salivary glands were taken, homogenized, and examined by biochemical analyses. Biochemical analyses showed that submandibular salivary gland glutathione (GSH) level, superoxide dismutase (SOD) and glutathione-Stransferase (GST) activities decreased; malondialdehyde (MDA), sialic acid (SA) and nitric oxide (NO) levels, tissue factor activity increased significantly in the VA group compared to the control group. No significant changes were found in catalase and myeloperoxidase activities. In the VA group, LA administration caused significant increases in GSH and NO levels; decreases in MDA, SA levels and SOD, GST activities. These findings suggest that LA may offer a protective effect against VA-induced oxidative damage in the salivary glands, potentially through its antioxidant properties. This study highlights the therapeutic potential of LA in mitigating oxidative stress and tissue damage induced by VA.
dc.identifier.doi10.56042/ijbb.v62i6.16117
dc.identifier.endpage583
dc.identifier.issn0301-1208
dc.identifier.scopusqualityQ3
dc.identifier.startpage576
dc.identifier.urihttps://hdl.handle.net/11363/10049
dc.identifier.volume62
dc.indekslendigikaynakScopus
dc.institutionauthorAlev-Tüzüner, Burçin
dc.institutionauthoridhttps://orcid.org/0000-0001-5122-4977
dc.language.isoen
dc.publisherNational Institute of Science Communication and Policy Research
dc.relation.ispartofIndian Journal of Biochemistry and Biophysics
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlpha lipoic acid
dc.subjectAntioxidant parameters
dc.subjectOxidative stress
dc.subjectSubmandibular salivary gland
dc.subjectValproic acid
dc.titleThe effects of lipoic acid on rat submandibular salivary gland in valproic acid induced oxidative stress
dc.typeArticle

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