Could cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing country

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dc.authoridhttps://orcid.org/0000-0002-6586-8092en_US
dc.contributor.authorKuş Silav, Zuhal
dc.contributor.authorSönmez, Cansu
dc.contributor.authorAydemir, Bülent
dc.contributor.authorYıldırım, Mehmet
dc.contributor.authorOkay, Tamer
dc.contributor.authorVardar Aker, Fügen
dc.date.accessioned2023-11-02T11:26:51Z
dc.date.available2023-11-02T11:26:51Z
dc.date.issued2023en_US
dc.departmentSağlık Hizmetleri Meslek Yüksekokuluen_US
dc.description.abstractBackground: The diagnostic performance of cytology was compared with the frozen results and its usability was evaluated as a rapid diagnosis method in intraoperative thoracic surgery in a single institution (Istanbul, Turkey). Methods: All 197 subsequent patient specimens (cases) from 158 patients who were sent to our department from the thoracic surgery clinic for an intraoperative diagnosis request between the years 2016 and 2021 were evaluated. Obtained results from frozen and cytology were compared with final paraffin section diagnoses. Lesions were grouped into three different groups as nonneoplastic, benign, and malignant neoplasms. Results: Diagnostic accuracy values of cytology and frozen sections in intraoperative consultation were 98.8% and 99.4%, respectively. Sensitivity values of cytology and frozen sections in intraoperative consultation were 96.3% and 98.7%, respectively. Specificity values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Negative predictive values of cytology and frozen sections in intraoperative consultation were 96.7% and 98.9%, respectively. Positive predictive values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Kappa statistics between cytology and frozen revealed a very high interrater reliability (Cohen's Kappa value: 0.911; p = .001; p < .01). The difficulty in distinguishing primary and metastatic carcinoma, which is mostly undecided in frozen sections and the definitive diagnosis is left to paraffin sections, seems also be a problem in the cytological examination. Conclusions: Cytological diagnosis can be used in the evaluation of small biopsy specimens that require tissue preservation in intraoperative consultation, especially for immunohistochemical and advanced genetic studies.en_US
dc.identifier.doi10.1002/dc.25060en_US
dc.identifier.endpage134en_US
dc.identifier.issn8755-1039
dc.identifier.issn1097-0339
dc.identifier.issue2en_US
dc.identifier.pmid36181474en_US
dc.identifier.scopus2-s2.0-85139082912en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://hdl.handle.net/11363/6184
dc.identifier.urihttps://doi.org/
dc.identifier.volume51en_US
dc.identifier.wosWOS:000862421900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKuş Silav, Zuhal
dc.language.isoenen_US
dc.publisherWILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJen_US
dc.relation.ispartofDiagnostic Cytopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectintraoperative diagnosisen_US
dc.subjectpulmonary pathologyen_US
dc.subjectscratch-imprint cytologyen_US
dc.titleCould cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing countryen_US
dc.typeArticleen_US

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