rs3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder cancer

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dc.authoridTiryakioglu, necip ozan/0000-0002-3122-3050
dc.authoridTUNALI, Nagehan ERSOY/0000-0001-5460-3569
dc.authoridPence, Sadrettin/0000-0001-9453-4166
dc.authoridTunali, Halil/0000-0002-8729-1087
dc.authoridPENCE, HALIME HANIM/0000-0002-8346-1018
dc.contributor.authorPence, S.
dc.contributor.authorOzbek, E.
dc.contributor.authorTiryakioglu, N. Ozan
dc.contributor.authorTunali, N. Ersoy
dc.contributor.authorPence, H. H.
dc.contributor.authorTunali, H.
dc.date.accessioned2024-09-11T19:52:34Z
dc.date.available2024-09-11T19:52:34Z
dc.date.issued2017
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractTo study the role of MMP9 and TIMP2 genotypes and expression in predisposition to bladder cancer and relation with metastasis. 100 urinary bladder cancer patients and 100 healthy controls were included in the study. rs3918242 and rs8179090 genotypes were determined with PCR-RFLP. Quantitative real-time polymerase chain reaction was employed to assess the MMP-9 and TIMP-2 expression in tumors and adjacent healthy tissues. Variant genotype (TT) for rs3918242 polymorphism and rs8179090 variant genotype are not associated with bladder cancer risk. rs3918242 genotype was significantly associated with tumor invasion. In contrast with this, rs8179090 genotype has not shown a significant association with tumor invasion. Both SNPs did not show a significant association with metastatic status. MMP-9 was upregulated in tumors in comparison to cancer free tissues. Significant increase in the expression of MMP-9 was also observed in invasive tumors. TIMP-2 expression was significantly increased in tumors in comparison to cancer free tissues and in metastatic tumors in comparison to non-metastatic tumors. Tissues with rs3918242 variant genotype have shown increased MMP-9 expression. rs3918242 promoter polymorphism of MMP-9 is significantly associated with tumor invasion, however; there is no positive correlation between TIMP-2 rs8179090 promoter polymorphism variant frequency and invasion. MMP-9 and TIMP-2 genes are upregulated in cancerous tissues when compared to normal bladder tissues.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Istanbul University [25472]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Project Coordination Unit of Istanbul University. Project number: 25472.en_US
dc.identifier.doi10.14715/cmb/2017.63.9.9
dc.identifier.endpage52en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue9en_US
dc.identifier.pmid28980922en_US
dc.identifier.scopus2-s2.0-85030623588en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.9.9
dc.identifier.urihttps://hdl.handle.net/11363/7978
dc.identifier.volume63en_US
dc.identifier.wosWOS:000418148100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular And Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectBladder canceren_US
dc.subjectPolymorphismen_US
dc.subjectMMP-9en_US
dc.subjectTIMP-2en_US
dc.subjectrs3918242en_US
dc.subjectrs8179090en_US
dc.titlers3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder canceren_US
dc.typeArticleen_US

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