EFFECTS OF GENETIC VARIATIONS OF MLCK2, AMPD1, AND COL5A1 ON MUSCLE ENDURANCE

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dc.authoridKucukhuseyin, Ozlem/0000-0001-6298-5026
dc.authoridAslan, Halid Emre/0000-0003-3690-2367
dc.authoridKaraagac, Ali/0000-0002-4327-7347
dc.authoridYaylim, Ilhan/0000-0003-2615-0202
dc.contributor.authorHorozoglu, Cem
dc.contributor.authorAslan, Halid Emre
dc.contributor.authorKaraagac, Ali
dc.contributor.authorKucukhuseyin, Ozlem
dc.contributor.authorBilgic, Tugce
dc.contributor.authorHimmetoglu, Solen
dc.contributor.authorGheybi, Arezoo
dc.date.accessioned2024-09-11T19:52:39Z
dc.date.available2024-09-11T19:52:39Z
dc.date.issued2022
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractIntroduction: Although potential relationships with genetic variants of MLCK2, AMPD1 and COL5A1 have been detected in molecular studies evaluating sports performance from the genetic perspective, there are limited data in terms of muscle endurance and physical fitness. Materials and Methods:This study aimed to evaluate these variants in terms of lower limb muscle endurance and physical fitness in thirty-three soccer players. Genotypes were determined by High Resolution Melting (HRM) analysis in qPCR after genomic DNA was isolated from buccal swab samples from the participants. Measurements of lower limb muscle endurance, the dynamic leap and balance test (DLBT), and the standing broad jump test (SBJ) were taken for all the participants. Results: Greater height (p = 0.006), higher DLBT (p = 0.016) and SBJ (p = 0.033) scores, as well as greater left hip adduction (p <0.001), were detected in those with the CT genotype for AMPD1 as compared to those with CC. For MLCK rs28497577, it was found that the players carrying the AA genotype were taller (p = 0.046), heavier (p = 0.049), and had greater left knee extension (p=0.014) and left foot plantar flexion (p =0.040) than those carrying the C allele.Those with the CT genotype for COL5A1 rs12722 had greater right hip extension (p = 0.040) and right knee extension (p = 0.048) than those with the CC genotype. Conclusions: Our results showed that MLCK2 and COL5A1 gene variants are associated with body composition and lower limb muscle endurance, and the presence of the AMPD1 CT genotype may contribute positively to balance, correct positioning, controlled strength, and hip mobility. Evidence level II; Comparative prospective study.en_US
dc.identifier.doi10.1590/1517-8692202228042021_0180
dc.identifier.endpage266en_US
dc.identifier.issn1517-8692
dc.identifier.issn1806-9940
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1590/1517-8692202228042021_0180
dc.identifier.urihttps://hdl.handle.net/11363/8002
dc.identifier.volume28en_US
dc.identifier.wosWOS:000779163700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Brasileira Med Esporteen_US
dc.relation.ispartofRevista Brasileira De Medicina Do Esporteen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectSkeletal muscleen_US
dc.subjectAthletic performanceen_US
dc.subjectGenetic variationen_US
dc.titleEFFECTS OF GENETIC VARIATIONS OF MLCK2, AMPD1, AND COL5A1 ON MUSCLE ENDURANCEen_US
dc.typeArticleen_US

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