Ultrasonographic analysis of palatal donor site healing accelerated with platelet-rich fibrin following subepithelial connective tissue harvesting

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dc.authoridAçıkgöz, Gözde/0000-0003-0147-1798
dc.authoridOZLU UCAN, GULFEM/0000-0002-0720-3447
dc.contributor.authorTorumtay Cin, Gizem
dc.contributor.authorLektemur Alpan, Aysan
dc.contributor.authorAçıkgöz, Gözde
dc.contributor.authorÖzlü Uçan, Gülfem
dc.date.accessioned2024-09-11T19:52:40Z
dc.date.available2024-09-11T19:52:40Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractObjective: Platelet-rich fibrin (PRF) contains a variety of growth factors and bioactive molecules that play crucial roles in wound healing and angiogenesis. We aimed to evaluate the effects of PRF on tissue thickness and vascularization of the palatal donor site by ultrasound (USG) following subepithelial connective tissue harvesting. Methodology: A subepithelial connective tissue graft was harvested from the palatal region with a single incision for root coverage in 20 systemically healthy patients. In the test group (n = 10), the PRF membrane was placed at the donor site, whereas no material was applied in the control group (n=10). Palatal tissue thickness (PTT) and pulsatility index (PI) were evaluated by USG at baseline and on the 3rd, 7th, 14th, 30th, and 90th days after surgery. The early healing index (EHI) was used to evaluate donor site healing for 30 days. Results: PTT was significantly higher in the PRF group on the 3rd and 14th days after surgery when compared to the controls. In the PRF-treated group, PI levels were significantly higher than in the controls, especially on the 14th day. PTT increased significantly 90 days after surgery compared to the test group baseline, but controls showed a significant decrease. The PRF group showed statistically significant improvements in EHI scores compared to controls on days 3, 7, and 14. This study found a negative correlation between PI values and EHI scores on postoperative days three and seven in the test group. Conclusion: USG is a non-invasive, objective method to radiographically evaluate the regenerative effects of PRF on palatal wound healing after soft tissue harvesting. To overcome graft inadequacy in reharvesting procedures, PRF application may enhance clinical success and reduce possible complications by increasing tissue thickness and revascularization in the donor area.en_US
dc.identifier.doi10.1590/1678-7757-2023-0448
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.pmid38655988en_US
dc.identifier.scopus2-s2.0-85191364454en_US
dc.identifier.urihttps://doi.org/10.1590/1678-7757-2023-0448
dc.identifier.urihttps://hdl.handle.net/11363/8003
dc.identifier.volume32en_US
dc.identifier.wosWOS:001217773800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo Fac Odontologia Bauruen_US
dc.relation.ispartofJournal of Applied Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectPlatelet-rich fibrinen_US
dc.subjectUltrasonographyen_US
dc.subjectWound healingen_US
dc.subjectBlood flowen_US
dc.subjectPalateen_US
dc.subjectRegenerationen_US
dc.titleUltrasonographic analysis of palatal donor site healing accelerated with platelet-rich fibrin following subepithelial connective tissue harvestingen_US
dc.typeArticleen_US

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