Efficacy of ozone therapy as an add-on treatment in fibromyalgia: A randomized double-blind placebo-controlled study

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dc.contributor.authorSucuoglu, Hamza
dc.contributor.authorSoydas, Nalan
dc.date.accessioned2024-09-11T19:53:05Z
dc.date.available2024-09-11T19:53:05Z
dc.date.issued2023
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractBACKGROUND: Fibromyalgia (FM) is a chronic disease that causes widespread pain, fatigue, and sleep disturbance. There is still no effective definitive treatment method; therefore, the search for treatment continues. OBJECTIVE: The purpose of this study is to investigate the effectiveness of ozone therapy (OT), which has been used in FM treatment in recent years, as an additional treatment. METHODS: The patients were divided into OT (n = 26) and placebo control (PC) (n = 28) groups. Both groups received OT in the form of major autohemotherapy (MaAHT) and minor autohemotherapy (MiAHT) for two sessions per week for a total of 10 sessions. The fibromyalgia impact questionnaire (FIQ), Pittsburgh sleep quality index (PSQI), and 12-item short-form health survey (SF-12) were used for evaluation pre- and post-intervention. RESULTS: In the between-group comparison, the OT group showed significant post-treatment improvements in FIQ subscales (feel good, fatigue) and PSQI total score and subscales (subjective sleep quality, sleep latency and sleep disturbances) compared to the PC group (p < 0.05). Although there were improvements in the FIQ total score post-treatment in both groups, there was no significant difference between the groups ( p > 0.05). CONCLUSION: OT, which is applied as an additional treatment with the autohemotherapy method, simultaneously improves the subscale scores (feel good and fatigue) of FM and sleep quality in the treatment period. However, changes in the post-treatment FIQ total score were not different in the ozone therapy group from the placebo control group.en_US
dc.identifier.doi10.3233/BMR-210368
dc.identifier.endpage366en_US
dc.identifier.issn1053-8127
dc.identifier.issn1878-6324
dc.identifier.issue2en_US
dc.identifier.pmid36530072en_US
dc.identifier.scopus2-s2.0-85151044956en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://doi.org/10.3233/BMR-210368
dc.identifier.urihttps://hdl.handle.net/11363/8062
dc.identifier.volume36en_US
dc.identifier.wosWOS:000952014500010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofJournal of Back And Musculoskeletal Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectAutohemotherapyen_US
dc.subjectfibromyalgiaen_US
dc.subjectozoneen_US
dc.subjectquality of lifeen_US
dc.subjectsleepen_US
dc.titleEfficacy of ozone therapy as an add-on treatment in fibromyalgia: A randomized double-blind placebo-controlled studyen_US
dc.typeArticleen_US

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