Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles

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dc.authoridGoren, Ahmet Ceyhan/0000-0002-5470-130X
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridbingol, zeynebe/0000-0003-3373-779X
dc.authoridUc, Eda Mehtap/0000-0002-9259-5704
dc.contributor.authorMutlu, Muzaffer
dc.contributor.authorBingol, Zeynebe
dc.contributor.authorUc, Eda Mehtap
dc.contributor.authorKoksal, Ekrem
dc.contributor.authorGoren, Ahmet C.
dc.contributor.authorAlwasel, Saleh H.
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-09-11T19:53:10Z
dc.date.available2024-09-11T19:53:10Z
dc.date.issued2023
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractIn this study, for the first time, the antioxidant and antidiabetic properties of the essential oil from cinnamon (Cinnamomum zeylanicum) leaves were evaluated and investigated using various bioanalytical methods. In addition, the inhibitory effects of cinnamon oil on carbonic anhydrase II (hCA II), acetylcholinesterase (AChE), and alpha-amylase, which are associated with various metabolic diseases, were determined. Further, the phenolic contents of the essential oil were determined using LC-HRMS chromatography. Twenty-seven phenolic molecules were detected in cinnamon oil. Moreover, the amount and chemical profile of the essential oils present in cinnamon oil was determined using GC/MS and GC-FID analyses. (E)-cinnamaldehyde (72.98%), benzyl benzoate (4.01%), and trans-Cinnamyl acetate (3.36%) were the most common essential oils in cinnamon leaf oil. The radical scavenging activities of cinnamon oil were investigated using 1,1-diphenyl-2-picryl-hydrazil (DPPH center dot), 2,2 '-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), and (ABTS(center dot+)) bioanalytical scavenging methods, which revealed its strong radical scavenging abilities (DPPH center dot, IC50: 4.78 mu g/mL; and ABTS(center dot+), IC50: 5.21 mu g/mL). Similarly, the reducing capacities for iron (Fe3+), copper (Cu2+), and Fe3+-2,4,6-tri(2-pyridyl)-S-triazine (TPTZ) were investigated. Cinnamon oil also exhibited highly effective inhibition against hCA II (IC50: 243.24 mu g/mL), AChE (IC50: 16.03 mu g/mL), and alpha-amylase (IC50: 7.54 mu g/mL). This multidisciplinary study will be useful and pave the way for further studies for the determination of antioxidant properties and enzyme inhibition profiles of medically and industrially important plants and their oils.en_US
dc.description.sponsorshipKing Saud University, Saudi Arabia [RSP-2023/59]en_US
dc.description.sponsorshipThis study received no external funding.en_US
dc.identifier.doi10.3390/life13010136
dc.identifier.issn2075-1729
dc.identifier.issue1en_US
dc.identifier.pmid36676085en_US
dc.identifier.scopus2-s2.0-85146516571en_US
dc.identifier.urihttps://doi.org/10.3390/life13010136
dc.identifier.urihttps://hdl.handle.net/11363/8084
dc.identifier.volume13en_US
dc.identifier.wosWOS:000915621700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofLife-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240903_Gen_US
dc.subjectCinnamomum zeylanicumen_US
dc.subjectpolyphenolen_US
dc.subjectcinnamon oilen_US
dc.subjectantioxidant activityen_US
dc.subjectLC-HRMSen_US
dc.subjectGCMSen_US
dc.subjectenzyme inhibitionen_US
dc.titleComprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profilesen_US
dc.typeArticleen_US

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