Significance of Intercellular adhesion molecule-1 Lys496Glu gene polimorphism on plasma redox status regulation in laryngeal carcinoma

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dc.authoridAtayik, Mehmet Can/0000-0002-9869-0518
dc.authoridverim, ayşegül/0000-0002-6649-0837
dc.authoridCakatay, Ufuk/0000-0001-9861-7380
dc.contributor.authorYanar, Karolin
dc.contributor.authorAtayik, Mehmet Can
dc.contributor.authorHorozoglu, Cem
dc.contributor.authorDemirkol, Seyda
dc.contributor.authorSimsek, Bahadir
dc.contributor.authorVerim, Aysegul
dc.contributor.authorKucukhuseyin, Ozlem
dc.date.accessioned2024-09-11T19:53:15Z
dc.date.available2024-09-11T19:53:15Z
dc.date.issued2023
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractBackground:Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The present research is conducted to investigate whether specific gene polymorphism of ICAM-1 K469E (rs5498) and plasma redox status could be associated with laryngeal cancer (LC) development. Since there is no clear evidence which investigates the relationship between ICAM-1 polymorphism and ROS-mediated plasma protein oxidation in LC, our study is the first significant contribution for investigating the relationship.Methods:The study covered patients with primary LC and their age-matched healthy control subjects. Evaluation of ICAM-1 K469E (rs5498) gene polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Plasma redox status was assessed with spectrophotometric methods.Results:In the current paper, we found that LC patients with GG genotype had a decreasing trend for the plasma oxidative damage biomarker levels when compared with all allele genotypes (AA and AG).Conclusion:We concluded that G allele of the ICAM-1 K469E gene plays a significant role in the optimal regulation of plasma redox homeostasis in patients with LC.en_US
dc.identifier.doi10.4103/jcrt.jcrt_1081_21
dc.identifier.endpage1787en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue7en_US
dc.identifier.pmid38376278en_US
dc.identifier.scopus2-s2.0-85181440372en_US
dc.identifier.startpage1781en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.jcrt_1081_21
dc.identifier.urihttps://hdl.handle.net/11363/8103
dc.identifier.volume19en_US
dc.identifier.wosWOS:001134479700053en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240903_Gen_US
dc.subjectGene polymorphismsen_US
dc.subjectintercellular adhesion molecule 1en_US
dc.subjectlaryngeal canceren_US
dc.subjectoxidative stressen_US
dc.subjectplasma proteinsen_US
dc.titleSignificance of Intercellular adhesion molecule-1 Lys496Glu gene polimorphism on plasma redox status regulation in laryngeal carcinomaen_US
dc.typeArticleen_US

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