Investigation Of Gst And Drug Resistance Protein Expressions in Relation To Chemotherapy in Breast Cancer

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dc.authoridhttps://orcid.org/0000-0002-3689-3061
dc.authoridhttps://orcid.org/0000-0002-1377-2021
dc.authoridhttps://orcid.org/0000-0002-5892-3735
dc.authoridhttps://orcid.org/0000-0002-1280-4204
dc.authoridhttps://orcid.org/0000-0001-6639-9593
dc.authoridhttps://orcid.org/0000-0002-8967-7303
dc.contributor.authorKoçdoğan, Arzu Kaya
dc.contributor.authorKılıç, Murat
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorBenzer, Emine
dc.contributor.authorDilek, Gülay
dc.contributor.authorKahraman, Yavuz Selim
dc.contributor.authorGülçelik, Mehmet Ali
dc.date.accessioned2025-06-20T07:40:15Z
dc.date.available2025-06-20T07:40:15Z
dc.date.issued2025
dc.departmentSağlık Hizmetleri Meslek Yüksekokulu
dc.description.abstractBackground. During cancer therapy, resistance to chemotherapeutic agents is common and often linked to multidrug resistance mechanisms. Glutathione S-transferases (GSTs) and ATP-binding cassette (ABC) transporters, including multidrug resistance (MDR) proteins, multidrug resistance-associated proteins (MRPs), and breast cancer resistance protein (BCRP), are implicated in drug resistance. Material and methods. Protein expressions were determined in the tumor and surrounding tumor free breast tissues of 145 breast cancer patients by immunohistochemistry technique. Among 145 patients, 50 received preoperative (neoadjuvant) chemotherapy, and 95 received postoperative (adjuvant) chemotherapy. Results. In 50 neoadjuvant breast cancer patients, GSTA1, GSTK1, GSTM1, GSTO1, GSTP1, GSTS1, GSTT1, GSTZ1, MDR1, MRP1, MRP2, MRP3, MRP7, and BCRP expressions were higher in tumor epithelium compared to normal epithelium (p<0.05). In 95 adjuvant breast cancer patients, GSTA1, GSTK1, GSTM1, GSTP1, GSTT1, GSTZ1, MDR1, MRP1, MRP2, and MRP3 expressions were higher in tumor epithelium than in normal epithelium (p<0.05). GSTP1, GSTT1, and MRP3 expressions were significantly higher in neoadjuvant compared to adjuvant-treated breast cancer patients’ tumor tissues (p<0.05). Conclusions. GSTP1, GSTT1, and MRP3 may be important in inactivating the chemotherapeutic agents used in platinum-based treatment and are thus responsible for the drug resistance in breast cancer patients.
dc.identifier.citationKocdogan Kaya A, Kilic M, Oguztuzun S, Benzer E, Dilek G, Kahraman YS, et al. Investigation of GST and drug resistance protein expressions in relation to chemotherapy in breast cancer. Health Prob Civil. 2025; 19(2): 148-162. https://doi.org/10.5114/hpc.2024.139094
dc.identifier.doi10.5114/hpc.2024.139094
dc.identifier.endpage162
dc.identifier.issn2353-6942
dc.identifier.issn2354-0265
dc.identifier.issue2
dc.identifier.startpage148
dc.identifier.urihttps://hdl.handle.net/11363/9959
dc.identifier.volume19
dc.identifier.wos001496745100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKoçdoğan, Arzu Kaya
dc.institutionauthoridhttps://orcid.org/0000-0002-3689-3061
dc.language.isoen
dc.publisherJohn Paul II Univ Biala Podlaska, Sidorska 95/97, Biala Podlaska 21-500, POLAND
dc.relation.ispartofHEALTH PROBLEMS OF CIVILIZATION
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmultidrug resistance
dc.subjectGST
dc.subjectdrug resistance
dc.subjectbreast cancer
dc.subjectchemotherapy
dc.titleInvestigation Of Gst And Drug Resistance Protein Expressions in Relation To Chemotherapy in Breast Cancer
dc.typeArticle

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