The Effects of Lipoic Acid on Markers of Oxidative Stress and Inflammation in the Lungs of Valproic Acid-Treated Rats

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dc.authoridhttps://orcid.org/0000-0001-5122-4977
dc.authoridhttps://orcid.org/0000-0003-2789-5943
dc.authoridhttps://orcid.org/0000-0003-1193-168X
dc.authoridhttps://orcid.org/0000-0003-0804-1475
dc.authoridhttps://orcid.org/0000-0002-2091-9298
dc.authoridhttps://orcid.org/0000-0003-2419-8587
dc.authoridhttps://orcid.org/0000-0003-4185-4363
dc.authoridhttps://orcid.org/0000-0002-8258-6118
dc.contributor.authorAlev Tüzüner, Burçin
dc.contributor.authorTürkyılmaz Mutlu, İsmet Burcu
dc.contributor.authorİpekçi, Hazal
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorTunalı Akbay, Tuğba
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorYanardağ, Refiye
dc.contributor.authorYarat, Ayşen
dc.date.accessioned2025-03-27T12:50:40Z
dc.date.available2025-03-27T12:50:40Z
dc.date.issued2024
dc.departmentDiş Hekimliği Fakültesi
dc.description.abstractIn this experimental study, the effect of lipoic acid (LA) on lung damage caused by valproic acid (VPA) was investigated. The antioxidant, oxidative stress, and inflammation indicators such as glutathione (GSH), lipid peroxidation (LPO), catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), nitric oxide (NO), sialic acid (SA), myeloperoxidase (MPO), and tissue factor (TF) were examined. Sprague Dawley rats were used, and they were randomly divided into four groups as follows: Control group, LA group received 50 mg LA/kg/day for 15 days, VPA group received 500 mg VPA/kg/day for 15 days, and VPA+LA group received the same doses of VPA and LA for 15 days. On day 16, lung tissues were taken. VPA caused the decreases in GSH, SA and SOD values and the increases LPO, NO, and TF values. LA reversed the changes in GSH, SOD, and TF values. GST and CAT activities did not change significantly by the effect of VPA or LA. On the other hand, the inhibitory effect of VPA on MPO, which is an inflammatory marker, and the prooxidant effects of LA causing the increases in both LPO and MPO values were observed in lung tissue. These regulations may help LA to overcome oxidative stress caused by VPA in the lung. Further studies are needed to confirm the mechanism underlying VPA-induced MPO inhibition in the lung.
dc.identifier.citationALEV-TUZUNER, B., TURKYILMAZ, I. B., İPEKÇI, H., USTUNDAG, U. V., TUNALI-AKBAY, T., EMEKLI-ALTURFAN, E., YANARDAG, R., YARAT, A. (2024). The Effects of Lipoic Acid on Markers of Oxidative Stress and Inflammation in the Lungs of Valproic Acid-Treated Rats. Journal of the Turkish Chemical Society, Section A: Chemistry, 11(4),1441-1448. doi.org/10.18596/jotcsa.1520611
dc.identifier.doi10.18596/jotcsa.1520611
dc.identifier.endpage1448
dc.identifier.issn2149-0120
dc.identifier.issue4
dc.identifier.startpage1441
dc.identifier.urihttps://hdl.handle.net/11363/9616
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAlev Tüzüner, Burçin
dc.institutionauthoridhttps://orcid.org/0000-0001-5122-4977
dc.language.isoen
dc.publisherTurkish Chemical Society
dc.relation.ispartofJournal of the Turkish Chemical Society Section A: Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLung
dc.subjectLipoic acid
dc.subjectValproic acid
dc.subjectOxidative stress
dc.subjectAntioxidant
dc.titleThe Effects of Lipoic Acid on Markers of Oxidative Stress and Inflammation in the Lungs of Valproic Acid-Treated Rats
dc.typeArticle

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