Assessment of retinal thickness as a marker of brain masculinization in children with congenital adrenal hyperplasia: a pilot study

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dc.authoridONAL, HASAN/0000-0001-9676-7086
dc.authoridDoktur, Hilal/0000-0002-4494-3014
dc.authoridErsen, Atilla/0000-0002-2404-170X
dc.contributor.authorOnal, Hasan
dc.contributor.authorKutlu, Esra
dc.contributor.authorAydin, Banu
dc.contributor.authorErsen, Atilla
dc.contributor.authorTopal, Neval
dc.contributor.authorAdal, Erdal
dc.contributor.authorGunes, Hatice
dc.date.accessioned2024-09-11T19:52:37Z
dc.date.available2024-09-11T19:52:37Z
dc.date.issued2019
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractObjective: To investigate the relationship between brain masculinization and retinal thickness in children with congenital adrenal hyperplasia (CAH). Methods: Forty-five patients with CAH aged between 4 and 18 years and 30 age-matched healthy controls were included in this prospective study. Macular area was examined with optical coherence tomography (OCT); central subfield thickness (CST), cube volume (CV) and macular retinal thickness (MT) were measured in each subject. A gender identity questionnaire (GIQ) was used for the evaluation of gender happiness index. Results: Girls with CAH had a higher CV (p = 0.002) and MT (p = 0.003) than healthy girls. No significant difference was found between boys with CAH and healthy boys regarding the retinal thickness measurements. Mean CST, CV and MT were significantly higher in boys than in girls in the control group (p= 0.013, p <0.001, respectively), but there was no significant difference in those parameters between girls and boys with CAM. The gender happiness index was not different between healthy boys and boys with CAH, but was significantly lower in girls with CAH than healthy girls (p= 0.01). Conclusions: As retina is part of the brain, our finding appears to be a morphological evidence of the excess androgen exposure on brain structures in girls with CAH. In addition, we suggest using retinal thickness measurements as a marker of prenatal excess androgen exposure in future studies.en_US
dc.identifier.doi10.1515/jpem-2018-0397
dc.identifier.endpage687en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue7en_US
dc.identifier.pmid31199773en_US
dc.identifier.scopus2-s2.0-85067398623en_US
dc.identifier.startpage683en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2018-0397
dc.identifier.urihttps://hdl.handle.net/11363/7992
dc.identifier.volume32en_US
dc.identifier.wosWOS:000474203700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectcongenital adrenal hyperplasiaen_US
dc.subjectdisorders of sex developmenten_US
dc.subjectgender dysphoriaen_US
dc.subjectretinal thicknessen_US
dc.titleAssessment of retinal thickness as a marker of brain masculinization in children with congenital adrenal hyperplasia: a pilot studyen_US
dc.typeArticleen_US

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