Is there a relationship between infertility and fertilin ? protein distribution?

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dc.authoridIREZ, TULAY/0000-0001-8272-4931
dc.contributor.authorGundogan, Gul Ipek
dc.contributor.authorIrez, Tulay
dc.contributor.authorBozkurt, Hasan Hakan
dc.date.accessioned2024-09-11T19:51:20Z
dc.date.available2024-09-11T19:51:20Z
dc.date.issued2022
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractIntroduction: Fertilin 0 is a sperm surface protein that can mediate sperm-egg membrane interaction. This study was conducted to determine whether the expression of fertilin 0 after intrauterine insemination (IUI) in donors with normal parameters after standard semen analysis is related to low success rate or failure of fertilization. Methods: We examined the sperm of 30 male donors who have normal as controls, oligozoosper-mia, and unexplained infertility as the clinically indication for IUI. Fertilin 0 has been labeled with the ADAM2 antibody by indirect immunofluorescence (IF) assay. To evaluate the repro-ducibility of the test, we selected four sperm samples scale of 0 to +++ according to the distribution of fluorescence label. Results: The results were highly correlated with the corrected total cell fluorescence (CTCF) (Rp= 0.9972, P < 0.05). We suggest that the relationship between infertility and fertilin 0 may be due to the distribution of this protein on the sperm surface. Male partners of couples with unexplained infertility showed a low distribution of fertilin 0 by a decrease of the fluorescence signal in the IF labeling (scale of +++ by 7.4 +/- 10.32%, P < 0.0001, +/- SD). Discussion: Abnormal fertilin 0 function may be a potential mechanism that could lead to fertilization failure. (c) 2022 Asociacion Espan tilde ola de Andrologi acute accent a, Medicina Sexual y Reproductiva. Published by Else-vier Espan tilde a, S.L.U. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University; [21093]en_US
dc.description.sponsorshipFunding This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University. Project number: 21093en_US
dc.identifier.doi10.1016/j.rol.2021.04.003
dc.identifier.endpage248en_US
dc.identifier.issn1698-031X
dc.identifier.issue4en_US
dc.identifier.pmid35933293en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://doi.org/10.1016/j.rol.2021.04.003
dc.identifier.urihttps://hdl.handle.net/11363/7758
dc.identifier.volume20en_US
dc.identifier.wosWOS:000916957800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofRevista Internacional De Andrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectSpermen_US
dc.subjectFertilityen_US
dc.subjectUnexplained infertilityen_US
dc.subjectSurface proteinsen_US
dc.subjectOligozoospermiaen_US
dc.subjectAndrologyen_US
dc.titleIs there a relationship between infertility and fertilin ? protein distribution?en_US
dc.typeArticleen_US

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