Investigation of The Vitamin D Receptor (VDR) Gene Polymorphisms in Lumbar Disc Herniation in Turkish Patients

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dc.authorscopusid58642554200
dc.authorscopusid35740061200
dc.authorscopusid7006591747
dc.authorscopusid25229644200
dc.authorscopusid57222665560
dc.authorscopusid56449164600
dc.authorscopusid6603163490
dc.contributor.authorHekimoğlu, Bahar Toptaş
dc.contributor.authorEraltan, Hakan
dc.contributor.authorSarı, Hidayet
dc.contributor.authorHakan, Mehmet Tolgahan
dc.contributor.authorSönmez, Dilara
dc.contributor.authorHorozoğlu, Cem
dc.contributor.authorZeybek, Ümit
dc.date.accessioned2024-09-11T19:58:53Z
dc.date.available2024-09-11T19:58:53Z
dc.date.issued2019
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractObjective: Lumbar disc herniation (LDH) is a common degenerative disease. It is still not clear if there is a possible association between the vitamin D pathway and the etiopathogenesis of the disease. In this study, we investigated certain VDR polymorphisms which are known to affect vitamin D levels in patients with lumbar disc herniation. Material and Method: TaqI (rs731236) and Fok-I (rs2228570) poly-morphisms were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 72 LDH patients and 81 healthy controls. Results: After evaluation of our results, the frequency of LDH patients who have VDR Taq-I Tt genotype was significantly higher than the controls and carriers of Taq-I Tt genotype and t allele who had an increased risk for lumbar disc hernia cases, respectively p=0.002, OR:1.688, 95%CI:1.206-2.360; p=0.006, OR:1.420, 95%CI:1.104-1.825. VDR Fok-I genotypes did not differ significantly between lumbar disc herniation and control cases. (p=0.079). But, Ff genotype and f allele carriers had a higher risk for lumbar disk hernia than those with other genotypes, respectively p=0.025, OR:1.594, 95%CI:1.052-2.414; p=0.037, OR:1.514, 95%CI:1.019-2.250. Conclusion: Our study contributes to the identification of genetic risk factors for specific subgroups of patients with LDH, and em-phasizes the contribution of these biomarkers to the detailed clinical evaluation of patients with genetic biomarkers. © 2019, Istanbul University Press. All rights reserved.en_US
dc.description.sponsorshipIstanbul Üniversitesi, (4364)en_US
dc.description.sponsorshipFinancial Disclosure: This study was funded by Scientific Research Projects Coordination Unit of İstanbul University (Project number: 4364).en_US
dc.identifier.doi10.26650/experimed.2019.19017
dc.identifier.endpage98en_US
dc.identifier.issn2667-5846en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85114054081en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.26650/experimed.2019.19017
dc.identifier.urihttps://hdl.handle.net/11363/8568
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIstanbul University Pressen_US
dc.relation.ispartofExperimeden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240903_Gen_US
dc.subjectlumbar disc herniation; polymorphism; Vitamin D receptoren_US
dc.titleInvestigation of The Vitamin D Receptor (VDR) Gene Polymorphisms in Lumbar Disc Herniation in Turkish Patientsen_US
dc.title.alternativeLomber Disk Hernisi Tanısı Konan Türk Hastalarda Vitamin D Reseptör (VDR) Gen Polimorfizmlerinin Araştırılması]en_US
dc.typeArticleen_US

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