Postsynaptic potentials of soleus motor neurons produced by transspinal stimulation: a human single-motor unit study

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dc.authoridkaracan, ilhan/0000-0002-7462-1358
dc.authoridKnikou, Maria/0000-0002-6277-236X
dc.authoridYildiz, Nilgun/0000-0001-7632-9927
dc.contributor.authorYildiz, Nilgun
dc.contributor.authorCecen, Serpil
dc.contributor.authorSancar, Nuray
dc.contributor.authorKaracan, Ilhan
dc.contributor.authorKnikou, Maria
dc.contributor.authorTurker, Kemal S.
dc.date.accessioned2024-09-11T19:52:08Z
dc.date.available2024-09-11T19:52:08Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractTransspinal (or transcutaneous spinal cord) stimulation is a noninvasive, cost-effective, easily applied method with great potential as a therapeutic modality for recovering somatic and nonsomatic functions in upper motor neuron disorders. However, how transspinal stimulation affects motor neuron depolarization is poorly understood, limiting the development of effective transspinal stimulation protocols for rehabilitation. In this study, we characterized the responses of soleus alpha motor neurons to single-pulse transspinal stimulation using single-motor unit (SMU) discharges as a proxy given the 1:1 discharge activation between the motor neuron and the motor unit. Peristimulus time histogram, peristimulus frequencygram, and surface electromyography (sEMG) were used to characterize the postsynaptic potentials of soleus motor neurons. Transspinal stimulation produced short-latency excitatory postsynaptic potentials (EPSPs) followed by two distinct phases of inhibitory postsynaptic potentials (IPSPs) in most soleus motor neurons and only IPSPs in others. Transspinal stimulation generated double discharges at short interspike intervals in a few motor units. The short-latency EPSPs were likely mediated by muscle spindle group Ia and II afferents, and the IPSPs via excitation of group Ib afferents and recurrent collaterals of motor neurons leading to activation of diverse spinal inhibitory interneuronal circuits. Further studies are warranted to understand better how transspinal stimulation affects depolarization of alpha motor neurons over multiple spinal segments. This knowledge will be seminal for developing effective transspinal stimulation protocols in upper motor neuron lesions. NEW & NOTEWORTHY Transspinal stimulation produces distinct actions on soleus motor neurons: an early short-latency excitation followed by two inhibitions or only inhibition and doublets. These results show how transspinal stimulation affects depolarization of soleus alpha motor neurons in healthy humans.en_US
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health [R01HD100544]; New York State Department of Health [C38333GG]en_US
dc.description.sponsorshipResearch reported in this publication was supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number R01HD100544 and by the New York State Department of Health under Contract Number C38333GG (to Maria Knikou).en_US
dc.identifier.doi10.1152/jn.00077.2024
dc.identifier.endpage1111en_US
dc.identifier.issn0022-3077
dc.identifier.issn1522-1598
dc.identifier.issue6en_US
dc.identifier.pmid38656134en_US
dc.identifier.scopus2-s2.0-85194975021en_US
dc.identifier.startpage1101en_US
dc.identifier.urihttps://doi.org/10.1152/jn.00077.2024
dc.identifier.urihttps://hdl.handle.net/11363/7914
dc.identifier.volume131en_US
dc.identifier.wosWOS:001252278900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAmer Physiological Socen_US
dc.relation.ispartofJournal of Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectmotoneuronsen_US
dc.subjectmotor unitsen_US
dc.subjectpostsynaptic potentialsen_US
dc.subjecttranscutaneous spinal cord stimulationen_US
dc.subjecttransspinal stimulationen_US
dc.titlePostsynaptic potentials of soleus motor neurons produced by transspinal stimulation: a human single-motor unit studyen_US
dc.typeArticleen_US

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