Characterization of gelatin-based wound dressing biomaterials containing increasing coconut oil concentrations

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dc.authoridhttps://orcid.org/0000-0002-4814-6346en_US
dc.authoridhttps://orcid.org/0000-0001-6311-4302en_US
dc.contributor.authorKaramanlıoğlu, Mehlika
dc.contributor.authorYeşilkır Baydar, Serap
dc.date.accessioned2024-03-13T23:31:06Z
dc.date.available2024-03-13T23:31:06Z
dc.date.issued2024en_US
dc.departmentMühendislik ve Mimarlık Fakültesien_US
dc.description.abstractThis study determined the influence and ideal ratios of various coconut oil (CO) amounts in gelatin (G) based-films as wound dressings since there are limited comparative studies to evaluate the sole effect of increasing CO on protein-based biomaterials. Homogenous films at G:CO ratio of 4:0,4:2,4:3,4:4 (w:w) corresponding to CO-0, CO-2, CO-3, CO-4, respectively, were obtained using solution casting. SEM showed CO caused rougher surfaces decreasing mechanical strength. However, no pores were observed in CO-4 due to bigger clusters of oil improving stretchability compared to CO-3; and durability since aging of CO-4 was >10% lower than CO-0 in aqueous media. FTIR showed triglycerides’ band only in CO films with increasing amplitude. Moreover, amide-I of CO-2 was involved in more hydrogen bonding, therefore, CO-2 had the highest melt-like transition temperatures (Tmax) at ~163°C while others’ were at ~133°C; and had more ideal mechanical properties among CO films. XTT showed that increased CO improved 3T3 cell viability as CO-0 significantly decreased viability at 10,50,75,100?g/ mL (p<0.05), whereas CO-2 and CO-3 within 5-75?g/mL and CO-4 within 5-100?g/mL range increased viability ?100% suggesting proliferation. All CO samples at 25?g/mL stimulated 3T3 cell migration in Scratch Assay indicating wound healing. CO amounts mainly improved thermal and healing properties of gelatin-based biomaterial. CO-2 was more thermally stable and CO-4 had better influence on cell viability and wound healing than CO-0. Therefore, increased CO ratios, specifically 4:2 and 4:4, G:CO (w:w), in gelatin-based films can be ideal candidates for wound dressing materials.en_US
dc.identifier.doi10.1080/09205063.2023.2265624en_US
dc.identifier.endpage44en_US
dc.identifier.issn0920-5063
dc.identifier.issn1568-5624
dc.identifier.issue1en_US
dc.identifier.pmid37773094en_US
dc.identifier.scopus2-s2.0-85173676046en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage16en_US
dc.identifier.urihttps://hdl.handle.net/11363/7202
dc.identifier.urihttps://doi.org/
dc.identifier.volume35en_US
dc.identifier.wosWOS:001083149000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaramanlıoğlu, Mehlika
dc.institutionauthorYeşilkır Baydar, Serap
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTD2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLANDen_US
dc.relation.ispartofJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoconut oilen_US
dc.subjectgelatinen_US
dc.subjectwound dressingen_US
dc.subjectwound healingen_US
dc.subject3T3en_US
dc.subjectcytotoxicityen_US
dc.titleCharacterization of gelatin-based wound dressing biomaterials containing increasing coconut oil concentrationsen_US
dc.typeArticleen_US

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