Using intra-articular tranexamic acid in total knee replacement surgery with and without bleeding control: a prospective randomized double blind study

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dc.contributor.authorArslan, A.
dc.contributor.authorGormeli, G.
dc.date.accessioned2024-09-11T19:53:42Z
dc.date.available2024-09-11T19:53:42Z
dc.date.issued2018
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the effectiveness of tranexamic acid (TA) application in two techniques: in the first one wound closure is performed before the tourniquet is released; in the second one, wound closure is performed after the tourniquet is released. PATIENTS AND METHODS: The study is conducted on four groups of patients: (1) TA + TNR (tourniquet not released) where there is no bleeding control and TA is applied after wound closure without tourniquet release; (2) TA - TNR where placebo is applied after wound closure without tourniquet release; (3) TA + TR (tourniquet released) where tourniquet is released first and TA is applied after bleeding control and wound closure; and (4) TA - TR where tourniquet release is followed by bleeding control and placebo application. RESULTS: The amount of hemorrhage in hemovac drains in each group was as follows: 217.4 +/- 99.6 (100-590) ml in the TA + TNR group; 411.6 +/- 133.7 (175-850) ml in the TA - TNR group; 291.2 +/- 89.5 (160-650) ml in the TA + TR group; and 458.2 +/- 138.6 (200-920) ml in the TA - TR group (p<0.0001). The TA + TNR group differed significantly from other groups in terms of the hemorrhage in drains. Similarly, the TA + TNR group was notably different from the TA - TNR and TA - TR groups with regard to the hemoglobin and hematocrit values. CONCLUSIONS: The study reveals that the amount of blood in hemovac drains is reduced significantly after the application of tranexamic acid to the suprapatellar space in the technique where wound closure is performed without bleeding control and before the tourniquet is released.en_US
dc.identifier.endpage6132en_US
dc.identifier.issn1128-3602
dc.identifier.issue18en_US
dc.identifier.pmid30280800en_US
dc.identifier.scopus2-s2.0-85054409121en_US
dc.identifier.startpage6127en_US
dc.identifier.urihttps://hdl.handle.net/11363/8174
dc.identifier.volume22en_US
dc.identifier.wosWOS:000446228200049en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectTranexamic aciden_US
dc.subjectBleedingen_US
dc.subjectKneeen_US
dc.titleUsing intra-articular tranexamic acid in total knee replacement surgery with and without bleeding control: a prospective randomized double blind studyen_US
dc.typeArticleen_US

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