Effects of Local Application of Nano-silver on Osteomyelitis and Soft Tissue Infections: An Experimental Study in Rats

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dc.authorscopusid56073849400
dc.authorscopusid34974867500
dc.authorscopusid23768513300
dc.authorscopusid57184393500
dc.authorscopusid57114694400
dc.authorscopusid55912165100
dc.authorscopusid55968990300
dc.contributor.authorKemah, Bahattin
dc.contributor.authorUzer, Gökçer
dc.contributor.authorTurhan, Yalçln
dc.contributor.authorÖzturan, Burak
dc.contributor.authorKlllç, Bülent
dc.contributor.authorGültepe, Bilge Sümbül
dc.contributor.authorCeyran, Ayşe Bahar
dc.date.accessioned2024-09-11T19:58:25Z
dc.date.available2024-09-11T19:58:25Z
dc.date.issued2018
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractBone and soft tissue infections are among the least desired complications after orthopaedic surgery. This study analysed the effects of the local application of nano-silver particles (AgNPs) [1nm Combining double low line 1 billionth of a meter] in soft tissue infections. Materials-Method An experimental osteomyelitis model was formed by inoculating both tibias of 24 rats with methicillin-resistant. The rats were followed without treatment for 21 days. Blood samples and tibial x-rays at day 21 confirmed the development of infection. Then, the rats were divided randomly into two groups. One group (12 rats) underwent surgical debridement and received 21 days of teicoplanin therapy. The second group had the same treatment, with the addition of local nano-silver. All of the rats were sacrificed at day 42. Blood and wound swab samples were taken and the culture results were analysed. No differences were observed between the groups in healing values at pathological examination, or in changes in the number of colonies at days 21 and 42. No differences in white blood cell count (WBC) were observed between the groups before and after the treatment. idCombining double low line Although studies suggest the effectiveness of AgNPs on pathogens, we found that the application of nano-silver did not make any difference when used in addition to the classical osteomyelitis treatment with antibiotics and local surgical debridement. We believe that additional studies using repeated nano-silver application could be beneficial. © 2022 Geosci. Model Dev. All rights reserved.en_US
dc.identifier.doi10.7150/jbji.22121
dc.identifier.endpage49en_US
dc.identifier.issn2206-3552en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85103273908en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.7150/jbji.22121
dc.identifier.urihttps://hdl.handle.net/11363/8472
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCopernicus GmbHen_US
dc.relation.ispartofJournal of Bone and Joint Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240903_Gen_US
dc.titleEffects of Local Application of Nano-silver on Osteomyelitis and Soft Tissue Infections: An Experimental Study in Ratsen_US
dc.typeArticleen_US

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