Evaluation of Paraoxonase, Arylesterase, Dipeptidyl Peptidase-IV, Oxidative Stress, and Oxidative DNA Damage in Patients with Obsessive-Compulsive Disorder

Basit Öğe Kaydı
dc.authoridKOSE, HUSEYIN/0000-0003-3688-7195
dc.contributor.authorSağaltıcı, Eser
dc.contributor.authorBelli, Hasan
dc.contributor.authorKırankaya, Ayşegül
dc.contributor.authorKöse, Hüseyin
dc.contributor.authorUral, Cenk
dc.contributor.authorNamli, Mustafa Nuray
dc.contributor.authorDemirci, Onur Okan
dc.date.accessioned2024-09-11T19:52:02Z
dc.date.available2024-09-11T19:52:02Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractSome findings have emerged from the field of oxidative stress in patients with psychiatric disorders. These date also state that oxidative balance and obsessive-compulsive disorder (OCD) are significantly related. Yet, researchers have not investigated oxidative stress, oxidative balance, and DNA damage together. We tested the levels of paraoxonase-1 (PON1), and arylesterase (ARE). We also tested the dipeptidyl peptidase-IV (DPP-IV), oxidative stress, and oxidative DNA damage. We enrolled 37 patients with OCD in the study. The diagnosis of OCD according to DSM-V criteria was established. Patients had not received treatment for at least 6 months. The controls were matched with the patients about sex, age, body mass index (BMI), and smoking. Clinicians used the sociodemographic information form. All subjects were evaluated with a semi-structured questionnaire. Serum PON1, ARE, DPP-IV, oxidative stress index (OSI), and 8-hydroxideoxiguanosine (8-OHdG) calculations were conducted in the biochemical laboratory. PON1 and DPP-IV levels were not different between OCD patients and the control group (P > 0.05). An oxidative DNA damage marker 8-OHdG-and OSI were higher in the patient's group (p < 0.05). But levels of ARE were significantly lower in OCD patients (P < 0.05). We found evidence that oxidative stress-induced parameters such as OSI, ARE, and 8-OHdG might be related to a specific pathologic state in patients with OCD. The findings may provide a rationale for treating the pathological processes.en_US
dc.identifier.doi10.1134/S1819712424010173
dc.identifier.endpage219en_US
dc.identifier.issn1819-7124
dc.identifier.issn1819-7132
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.1134/S1819712424010173
dc.identifier.urihttps://hdl.handle.net/11363/7896
dc.identifier.volume18en_US
dc.identifier.wosWOS:001232700000017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofNeurochemical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectparaoxonaseen_US
dc.subjectarylesteraseen_US
dc.subjectdipeptidyl peptidase-IVen_US
dc.subjectoxidative stressen_US
dc.subjectoxidative DNA damageen_US
dc.subjectOCDen_US
dc.titleEvaluation of Paraoxonase, Arylesterase, Dipeptidyl Peptidase-IV, Oxidative Stress, and Oxidative DNA Damage in Patients with Obsessive-Compulsive Disorderen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale / Article
Boyut:
321.19 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu