3D-printed polylactic acid (PLA)/polymethyl silsesquioxane (PMSQ)-based scaffolds coated with vitamin E microparticles for the application of wound healing

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dc.authoridsahin, ali/0000-0001-5594-1551
dc.authoridGunduz, Oguzhan/0000-0002-9427-7574
dc.contributor.authorAnjrini, Nasma
dc.contributor.authorKarabulut, Hatice
dc.contributor.authorUlag, Songul
dc.contributor.authorEge, Hasan
dc.contributor.authorNoberi, Cansu
dc.contributor.authorDogan, Ecem
dc.contributor.authorSahin, Ali
dc.date.accessioned2024-09-11T19:50:46Z
dc.date.available2024-09-11T19:50:46Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractSkin is part of the integumentary and excretory system, which helps protect the body against infections. The skin should be properly treated when it gets injured, which requires a long healing process. In this study, 15% (w/v) polylactic acid (PLA) and 1 and 2% (w/v) polymethylsilsesquioxane (PMSQ) scaffolds were fabricated using 3D printing technology, and the surfaces of each scaffold were coated with 5% ethylcellulose (EC)/vitamin E microparticles using the electrospray method. The morphologies of the scaffolds were characterized using a scanning electron microscope (SEM), and results showed that the pore sizes of the scaffolds ranged from 136 to 265 mu m. The vitamin E was completely released from the scaffolds within 5 h. MTT test was performed with fibroblast cells and results proved the biocompatibility of the scaffolds. These findings showed that the scaffolds may have good potential as a wound dressing material. The biodegradation test was performed in in vitro conditions and results showed that the surface coating with 5% EC/vitamin E microparticles on the 15% PLA/2% PMSQ scaffolds increased the degradation rate of the scaffolds.en_US
dc.identifier.doi10.1007/s42247-024-00711-3
dc.identifier.issn2522-5731
dc.identifier.issn2522-574X
dc.identifier.scopus2-s2.0-85193079171en_US
dc.identifier.urihttps://doi.org/10.1007/s42247-024-00711-3
dc.identifier.urihttps://hdl.handle.net/11363/7664
dc.identifier.wosWOS:001223831800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofEmergent Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectElectrosprayen_US
dc.subjectMicroparticlesen_US
dc.subjectPLAen_US
dc.subjectPMSQen_US
dc.subjectVitamin Een_US
dc.subjectWound healingen_US
dc.subject3D printingen_US
dc.title3D-printed polylactic acid (PLA)/polymethyl silsesquioxane (PMSQ)-based scaffolds coated with vitamin E microparticles for the application of wound healingen_US
dc.typeArticleen_US

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