Assessing the protective effects of chard on valproic acid-induced pancreatic complications

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dc.authoridhttps://orcid.org/0000-0001-5122-4977
dc.contributor.authorAlev Tüzüner, Burçin
dc.contributor.authorAk, Esin
dc.contributor.authorTunalı, Sevim
dc.contributor.authorİpekci, Hazal
dc.contributor.authorÜstundağ, Ünsal Veli
dc.contributor.authorTunalı Akbay, Tuğba
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorÇetinel, Şule
dc.contributor.authorYanardağ, Refiye
dc.contributor.authorYarat, Ayşen
dc.contributor.authorAhmad, Sarfraz
dc.date.accessioned2025-06-12T21:03:10Z
dc.date.available2025-06-12T21:03:10Z
dc.date.issued2024
dc.departmentDiş Hekimliği Fakültesi
dc.description.abstractValproic acid (VPA) treatment is known to potentially cause adverse effects, notably as the most common cause of druginduced acute pancreatitis. It is crucial to balance the therapeutic benefits and potential major side effects of VPA administration. Complications associated with VPA may arise from toxic VPA metabolites and alterations in antioxidant levels. While chard is well-known for its anti-hyperglycemic and antioxidant properties, there is a lack of research on its impact on the pancreas during VPA treatment. This study aimed to explore the possible protective effects of chard against VPA-induced complications in the pancreas using histological and biochemical approaches. Animals were separated into four groups: i) Control, ii) received chard (100 mg/kg), iii) received VPA (500 mg/kg), and iv) received VPA+Chard (in the same dosages and time). On the eighth day, the rats’ pancreatic tissue and blood specimens were collected. In the Chard and VPA+Chard groups, chard decreased blood glucose levels compared to the control and VPA groups. In comparison to the VPA group, the VPA+Chard group pancreatic glutathione level and catalase activity increased whereas malondialdehyde levels decreased. Furthermore, administration of chard to the control and VPA groups increased tissue factor activity and sialic acid level as compared to the VPA group. The histological findings confirmed the biochemical results. It is therefore concluded that chard has the potential to protect pancreatic tissue from VPA-induced complications by reducing lipid peroxidation and blood glucose while enhancing antioxidants and sialic acid levels.
dc.identifier.doi10.56042/ijbb.v61i9.11341
dc.identifier.endpage526
dc.identifier.issn0301-1208
dc.identifier.issn0975-0959
dc.identifier.startpage517
dc.identifier.urihttps://hdl.handle.net/11363/9912
dc.identifier.volume61
dc.identifier.wos001301258300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAlev Tüzüner, Burçin
dc.institutionauthoridhttps://orcid.org/0000-0001-5122-4977
dc.language.isoen
dc.publisherNATL INST SCIENCE COMMUNICATION-NISCAIR, DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
dc.relation.ispartofINDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntiepileptic drug
dc.subjectAntioxidant
dc.subjectBeta vulgaris L.var. cicla
dc.subjectOxidative stress
dc.subjectPancreas
dc.titleAssessing the protective effects of chard on valproic acid-induced pancreatic complications
dc.typeArticle

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