Cytotoxic and anti-migratory effects of polyphenolic compounds on breast cancer cells by altering Jam-A, LFA-1, and VLA-4 gene expression

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dc.authoridhttps://orcid.org/0000-0003-3906-977X
dc.contributor.authorÖzkara, Gülçin
dc.contributor.authorCeviz, Ayşe Begüm
dc.contributor.authorEronat, Allison Pinar
dc.contributor.authorPehlevan Karabıyık, Funda
dc.contributor.authorCandan, Gonca
dc.contributor.authorÖztürk, Oğuz
dc.contributor.authorYılmaz Aydoğan, Hülya
dc.date.accessioned2025-06-19T12:41:07Z
dc.date.available2025-06-19T12:41:07Z
dc.date.issued2025
dc.departmentSağlık Hizmetleri Meslek Yüksekokulu
dc.description.abstractThis study represents the initial research of the effects of a combination of the largest number (13) of different polyphenic substances (PFK5120), formulated based on the propolis content on cell viability, migration and expression of lymphocyte function-associated antigen-1 (LFA-1), very late antigen-4 (VLA-4) and junction adhesion molecule A (Jam-A) in breast cancer (BC) cells. PFK5120 negatively affected cell viability at a 5% concentration as compared with unexposed ones (p<0.001). Treatment with 20% PFK5120 for 48h down-regulated Jam-A in MCF-7 and MCF-10A, up-regulated LFA-1 in MCF-10A and MDA-MB-231, and down-regulated VLA-4 in MCF-10A and MDA-MB-231 (p<0.001). Furthermore, migration was found to be inhibited by PFK5120 at varying doses and times. Migration was completely inhibited by 35% PFK5120 treatment in MDA-MB-231, while even lower concentrations (10%) were effective in MCF-7. Current findings indicate that PFK5120 represents a valuable natural component of BC therapy through its cytotoxic and anti-migratory effects.
dc.identifier.citationGulcin Ozkara, Ayse Begum Ceviz, Allison Pinar Eronat, Funda Pehlevan Karabiyik, Gonca Candan, Oguz Ozturk & Hulya Yilmaz-Aydogan (28 Apr 2025): Cytotoxic and anti-migratory effects of polyphenolic compounds on breast cancer cells by altering Jam-A, LFA-1, and VLA-4 gene expression, Natural Product Research, DOI: 10.1080/14786419.2025.2494629
dc.identifier.doi10.1080/14786419.2025.2494629
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.urihttps://hdl.handle.net/11363/9954
dc.identifier.wos001477697700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.institutionauthorPehlevan Karabıyık, Funda
dc.institutionauthoridhttps://orcid.org/0000-0003-3906-977X
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
dc.relation.ispartofNATURAL PRODUCT RESEARCH
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPolyphenols
dc.subjectbreast cancer
dc.subjectcell migration
dc.subjectJam-A
dc.subjectLFA-1
dc.subjectVLA-4
dc.titleCytotoxic and anti-migratory effects of polyphenolic compounds on breast cancer cells by altering Jam-A, LFA-1, and VLA-4 gene expression
dc.typeArticle

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