Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer

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dc.contributor.authorBademler, Süleyman
dc.contributor.authorZırtıloğlu, Alişan
dc.contributor.authorSarı, Murat
dc.contributor.authorÜçüncü, Muhammed Zübeyr
dc.contributor.authorDoğru, Elif Bilgin
dc.contributor.authorKarabulut, Senem
dc.date.accessioned2019-08-31T23:21:35Z
dc.date.available2019-08-31T23:21:35Z
dc.date.issued2019en_US
dc.departmentSağlık Bilimleri Yüksekokuluen_US
dc.description.abstractThis study was conducted to investigate the serum levels of membrane-bound mucin 2 (MUC2) in breast cancer (BC) patients and the relationship with tumour progression and known prognostic parameters. We enrolled 127 female patients with histopathologically diagnosed BC who did not receive chemotherapy (CT) or radiotherapy. Serum MUC2 levels were measured by the enzyme-linked immunosorbent assay (ELISA) method and compared with those of 40 age and sex-matched healthy controls. Median age of diagnosis was 50 (range: 26-78). Twenty-eight (22%) patients were metastatic and the most frequent site of metastasis was bone (n = 17, 61%). The median serum MUC2 level of BC patients was significantly higher than that of the controls (198 vs. 54 ng/mL, p < 0.001). There was no significant difference between patients and controls according to known disease-related clinicopathological or laboratory parameters (p > 0.05). Serum MUC2 levels were not associated with survival (p = 0.65). Although serum MUC2 levels might have a diagnostic role, their predictive and prognostic role in survival in BC patients was not detected. Serum levels of MUC2 should be investigated for diagnostic or screening purposes on a larger scale.en_US
dc.identifier.doi10.3390/biom9020040en_US
dc.identifier.issn2218-273X
dc.identifier.issue2en_US
dc.identifier.pmid30682816en_US
dc.identifier.scopus2-s2.0-85060511671en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://hdl.handle.net/11363/1430
dc.identifier.urihttps://doi.org/
dc.identifier.volume9en_US
dc.identifier.wosWOS:000460699000004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLANDen_US
dc.relation.ispartofBIOMOLECULESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectbreast canceren_US
dc.subjectMUC2en_US
dc.subjectserumen_US
dc.subjectdiagnosticen_US
dc.subjectEXPRESSIONen_US
dc.subjectPATHOGENESISen_US
dc.subjectMUC5ACen_US
dc.subjectSTATISTICSen_US
dc.subjectCARCINOMAen_US
dc.subjectMEDICINEen_US
dc.titleClinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Canceren_US
dc.typeArticleen_US

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