Evaluation of Antioxidant Potential of Noni ( Morinda citrifolia L. ) Fruit Juice against 3Methyl-4-nitrophenol (PNMC)-Induced Acute Nephrotoxicity in Rats

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dc.contributor.authorYigit, Funda
dc.contributor.authorEsener, Osman Behzat Burak
dc.contributor.authorTunali, Muzaffer Basak
dc.contributor.authorAktas, Abit
dc.contributor.authorSari, Ataman Bilge
dc.contributor.authorOzturk, Gulay Yuzbasioglu
dc.contributor.authorGurevin, Ebru Gurel
dc.date.accessioned2024-09-11T19:53:04Z
dc.date.available2024-09-11T19:53:04Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractThe 3-methyl-4-nitrophenol (PNMC), found in pesticides and diesel exhaust particles (DEP), increases oxidative stress and induces tissue injury, while Noni ( Morinda citrifolia L ) is known for its antioxidant and anti-apoptotic properties. This study aimed to investigate the potential benefits of Noni juice on PNMCinduced nephrotoxicity in rats. A total of 56 adult male Sprague-Dawley rats were randomly divided into eight groups (n=7 each). These groups included: Control (PBS+0.05% Tween 80 S/C), Noni (2 ml Noni juice per rat), 1 mg/kg PNMC, 10 mg/kg PNMC, 100 mg/kg PNMC, Noni+1 mg/kg PNMC, Noni+10 mg/kg PNMC and Noni+100 mg/kg PNMC. Noni juice was given @ 2ml per rat through oral gavage, while PNMC was given through S/C injections. Treatments were given daily for five days. Then the rats were euthanized and blood samples were collected for serum biochemical analysis and assessing oxidative stress status. Kidneys were processed for histopathological and ultrastructural analyses and immunohistochemical demonstration of iNOS, eNOS, NGAL, active caspase-3 expressions and apoptotic index. The iNOS protein level was also assessed by ELISA. Results showed dose-dependent increasing degenerative changes in the kidneys with 1, 10 and 100 mg/kg of PNMC. The severity of these lesions was reduced in Noni+PNMC treatment groups. Mitochondrial damage occurred with 100mg/kg PNMC. A significant dose-dependent increase was recorded in iNOS, eNOS, NGAL and active caspase-3 expressions and apoptotic index in the kidneys with PNMC, while these parameters were decreased with Noni juice administration. Oxidative stress was highest with 100 mg/kg PNMC and decreased in Noni+PNMC groups. In conclusion, Noni juice efficiently attenuated PNMC-induced acute renal toxicity; however, its efficacy against PNMC induced chronic toxic effects need to be investigated.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [BAP-33141, ACIdot;P-49851, BEK-2017-24297, BEK-2016-20842]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Istanbul University [grant numbers BAP-33141, AC & Idot;P-49851, BEK-2017-24297 and BEK-2016-20842] .en_US
dc.identifier.doi10.29261/pakvetj/2024.201
dc.identifier.endpage534en_US
dc.identifier.issn0253-8318
dc.identifier.issn2074-7764
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85198582883en_US
dc.identifier.startpage526en_US
dc.identifier.urihttps://doi.org/10.29261/pakvetj/2024.201
dc.identifier.urihttps://hdl.handle.net/11363/8053
dc.identifier.volume44en_US
dc.identifier.wosWOS:001267786500018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherUniv Agriculture, Fac Veterinary Scienceen_US
dc.relation.ispartofPakistan Veterinary Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectNoni (Morinda citrifolia L. ) fruit juiceen_US
dc.subject3-methyl-4-nitrophenol (PNMC)en_US
dc.subjectAcute renalen_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectRatsen_US
dc.titleEvaluation of Antioxidant Potential of Noni ( Morinda citrifolia L. ) Fruit Juice against 3Methyl-4-nitrophenol (PNMC)-Induced Acute Nephrotoxicity in Ratsen_US
dc.typeArticleen_US

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