Neuroprotective effect of carvacrol in an experimental cerebral ischemia and reperfusion rat model

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dc.authorscopusid57967795300
dc.authorscopusid56033953500
dc.authorscopusid27867577100
dc.authorscopusid57211524435
dc.authorscopusid56033997900
dc.authorscopusid6603710997
dc.contributor.authorBaşaran, Mustafa
dc.contributor.authorÖztanir, Mustafa Namık
dc.contributor.authorÇıftçı, Osman
dc.contributor.authorBaşak Türkmen, Neşe
dc.contributor.authorAkyuva, Yener
dc.contributor.authorÖnder, Arif
dc.date.accessioned2024-09-11T19:57:42Z
dc.date.available2024-09-11T19:57:42Z
dc.date.issued2022
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractThe Neuroprotective effect of carvacrol, which has anti-inflammatory and antioxidant effects, on infarcted cerebral tissue is present in literature, but this contribution was not sufficiently clarified in terms of biochemistry. It is aimed to investigate the effect of orally administered carvacrol on plasma and intraparenchymal levels of TBARS, GSH, SOD, CAT, GSH-Px, IL-1?, IL-4, and TNF-? after the formation of global ischemia in cerebral tissue. Four groups were formed, each containing ten Wistar albino rats. After anesthesia and analgesia, bilateral carotid communis arteries of rats in the first two groups were clamped for 15 minutes with aneurysm clips. Oral 50 mg/kg/day carvacrol was administered for 15 days to the first group (I/R+CRV) of these two groups in which cerebral ischemia-reperfusion (I/R) was established. On the other hand, %0,01 carboxymethylcellulose (CMC), which is a solvent of carvacrol, at a same volume of first group was administered orally for the same duration to the other group in which also I/R was established (I/R+CMC). In the other two groups in which ischemia was not induced, only carotid artery dissections were made and sutured again. In these two groups, 50 mg/kg/day of carvacrol was administered to the first group (CRV). The Same dose of CMC was administered to the second group (control group). After all these treatments, plasma was collected, and brain tissue was dissected from all groups at the end of the 15th day. Carvacrol can be included in the possible treatment regimen of cerebral stroke with the help of other studies that can be supported on this topic. © 2022 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.identifier.doi10.52142/omujecm.39.2.28
dc.identifier.endpage458en_US
dc.identifier.issn1309-4483en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85142061949en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage454en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.39.2.28
dc.identifier.urihttps://hdl.handle.net/11363/8337
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240903_Gen_US
dc.subjectcarvacrol; CAT; CMC; GSH; GSH-Px; IL-1?; IL-4; ischemia reperfusion; SOD; TBARS; TNF-?en_US
dc.titleNeuroprotective effect of carvacrol in an experimental cerebral ischemia and reperfusion rat modelen_US
dc.typeArticleen_US

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