İstanbul Gelişim Üniversitesi Kurumsal Açık Erişim Arşivi
DSpace@Gelişim, İstanbul Gelişim Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The cruciality of environmental degradation, energy use and urbanization to policy framework for sustainable growth and development: evidence from Spain
(EMERALD GROUP PUBLISHING LTD, Floor 5, Northspring 21-23 Wellington Street, Leeds, W YORKSHIRE LS1 4DL, ENGLAND, 2025) Bekun, Festus Victor; Adebayo, Tomiwa Sunday; Agboola, Mary; Onifade, Stephen Taiwo; Awosusi, Abraham Ayobamiji
Purpose – Attaining a sustainable environment has become an international commitment. Therefore,
mitigating climate change concerns is pertinent for a sustainable ecosystem. This study aims to focus on the
Spanish economy, which has enjoyed some positive growth trends over the years. However, there remains an
unaddressed puzzle as to whether the experienced growth path is green or dirty given the wake of global
connectedness. These concerns are related to the objective of the sustainable development goals (SDGs) that
comprises economic growth (SDGs-8), climate issues (SDGs-13) and responsible energy consumption and
access to energy (SDGs-7, 12).
Design/methodology/approach – This research empirically explores the comovement and coherence
between CO2 emissions and its driving factors – specifically renewable energy, fossil fuel consumption,
urbanization and economic growth using the wavelet tools.
Findings – The result of the wavelet coherence shows that (i) renewable energy and CO2 emissions are
out-phase; (ii) economic growth and CO2 are in-phase; urbanization and CO2 are in-phase; and (iv)
fossil fuel and CO2 are in-phase. The result of the multiple wavelet coherence shows that CO2 in Spain
were strongly linked to urbanization, economic growth and energy consumption. While coherence
with renewable energy and urbanization weakened after 2000, fossil fuel reliance remained a key
driver.
Practical implications – These results are not desirable for the case study (Spain). Therefore, there is a
necessity for a gradual and more aggressive shift in the Spanish energy mix to renewables. The shift to
renewables is required for inclusive growth and a green growth path in Spain. Originality/value – In this study, the authors used wavelet tools, which help uncover hidden information
across different time-frequency domains. The importance of the ramifications of this research will also go
beyond a localized relevance to the Spanish economy alone, as there is relative applicability of some of the
practical implications from the study to other similar European Union (EU) countries considering Spain’s
stance in the EU in terms of geography, economics and politics.
Cytotoxic and anti-migratory effects of polyphenolic compounds on breast cancer cells by altering Jam-A, LFA-1, and VLA-4 gene expression
(TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, 2025) Özkara, Gülçin; Ceviz, Ayşe Begüm; Eronat, Allison Pinar; Pehlevan Karabıyık, Funda; Candan, Gonca; Öztürk, Oğuz; Yılmaz Aydoğan, Hülya
This study represents the initial research of the effects of a combination of the largest number (13) of different polyphenic substances (PFK5120), formulated based on the propolis content on
cell viability, migration and expression of lymphocyte
function-associated antigen-1 (LFA-1), very late antigen-4 (VLA-4)
and junction adhesion molecule A (Jam-A) in breast cancer (BC)
cells. PFK5120 negatively affected cell viability at a 5% concentration as compared with unexposed ones (p<0.001). Treatment
with 20% PFK5120 for 48h down-regulated Jam-A in MCF-7 and
MCF-10A, up-regulated LFA-1 in MCF-10A and MDA-MB-231, and
down-regulated VLA-4 in MCF-10A and MDA-MB-231 (p<0.001).
Furthermore, migration was found to be inhibited by PFK5120 at
varying doses and times. Migration was completely inhibited by
35% PFK5120 treatment in MDA-MB-231, while even lower concentrations (10%) were effective in MCF-7. Current findings indicate
that PFK5120 represents a valuable natural component of BC therapy through its cytotoxic and anti-migratory effects.
Unveiling the key dimensions shaping visitor experiences in cave tourism through a content analysis approach: the case of Antalya’s show caves
(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND, 2025) Tanrıverdi, Haluk; Çıkı, Kartal Doğukan; Öğretmenoğlu, Mert; Uygun, Nursaç
This research investigates the experiential dimensions of cave tourism by
analysing visitor experiences through user-generated content. A
qualitative case study approach was adopted, utilising TripAdvisor
reviews as the primary data source due to its relevance and widespread
use in tourism research. Visitor comments were collected over a 20-day
period between late July and early August 2024, covering reviews from
2019 to 2024. The findings reveal that cave tourism experiences
encompass five key dimensions: educational, aesthetic, escapism,
entertainment, and perceived benefits (e.g. health benefits and social
interaction). The originality of this research lies in its exploration of the
multifaceted experiences of cave visitors, highlighting the significance
of aesthetic, entertainment, educational, and escapist elements, along
with perceived benefits such as health and social interaction, in shaping
the overall visitor experience. The findings contribute to the literature
by offering empirical insights that inform strategic recommendations for
the sustainable development of cave tourism. In this regard, the
research proposes actionable suggestions to enhance service quality
and promote visitor satisfaction in cave tourism settings.
Exploration of the soliton solutions of the (n+1) dimensional generalized Kadomstev Petviashvili equation using an innovative approach
(NATURE PORTFOLIO, HEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY, 2025) Kopçasız, Bahadır; Sağlam, Fatma Nur Kaya; Bulut, Hasan; Radwan, Taha
In this paper, we deal with the (n+1)-dimensional generalized Kadomtsev-Petviashvili equation
(dgKPE). This is an important model in nonlinear science, with applications in various fields. Its
integrability and rich soliton dynamics continue to attract researchers interested in the field of
nonlinear partial differential equations (NLPDEs). We are interested in the new auxiliary equation
method (NAEM). We reduce the equation to an ordinary differential equation (ODE) with the help of an
appropriate wave transformation and search for different types of soliton solutions. Additionally, we
demonstrated the efficacy of the NAEM as a straightforward yet powerful mathematical instrument
for handling challenging issues, highlighting its potential to resolve the challenging problems related
to the study of nonlinear equations. This technique yields several types of solutions for (n+1)-dgKPE,
including trigonometric, hyperbolic, shock wave, singular soliton, exponential, and rational functions.
A range of graphs showcasing the results are reviewed, as well as the wave behavior for the solutions in
different circumstances. The obtained data provide important information for studying hydrodynamic
waves, plasma fluctuations, and optical solitons. They also aid in understanding the behavior of the
KPE in different physical situations. We clarify in this article how the (n+1)-dgKPE, when combined with
NAEM, can result in better data transmission rates, optimized optical systems, and the advancement
of nonlinear optics toward more dependable and efficient communication technologies. The obtained
information clarifies the equation and opens up new avenues for investigation. To our knowledge,
for this equation, these methods of investigation have not been utilized before. The accuracy of each
solution has been verified using the Maple software program.
Effects of Blood Flow Restriction Resistance Exercise Versus Traditional Resistance Exercise in Voluntary Exhaustion on Quadriceps Muscle Adaptations in Untrained Young Males: A Randomized Trial
(MDPI, MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND, 2025) Akgül, Mustafa Şakir; Uysal, Hüseyin Şahin; Keskin, Nevin Köremezli; Çetin, Tuğba; Başdemirci, Merve; Akgül, Melike Nur; Yıldız, Zehra; Çiftçi, Ebubekir; Soslu, Recep
Background and Objectives: This study compared the effects of blood flow restriction resistance exercise (BFR-RE) and high-load resistance exercise (HL-RE) in voluntary
exhaustion on quadriceps muscle adaptations in untrained young males. Materials and
Methods: This study used a randomized controlled design that included 30 untrained young
males (age = 21.42 ± 2.51). The BFR-RE group performed leg extension exercises with
60% occlusion pressure and 30% of one maximum repetition in volitional exhaustion. The
same exercise was conducted at 70% 1RM in the HL-RE group. Fourteen variables were
used to evaluate the intervention efficacy, including muscle thickness, stiffness, strength,
cross-sectional area (CSA), and subcutaneous fat thickness. Analyses were reported using
frequentist and Bayesian approaches. The Bayes factor (BF10 and BFincl) was interpreted
based on negative and positive values. Results: The results revealed that the main effect of
time was statistically significant for muscle strength, thickness, CSA, and stiffness (p < 0.05,
BFincl > 1) and, in intragroup comparisons, both groups showed improvements in these
parameters (p < 0.05, BF10 > 1). A statistically significant decrease in subcutaneous fat
thickness was observed in the BFR-RE group (p < 0.05, BF10 > 1), while this change was
not observed in the HL-RE group (p > 0.05, BF10 < 1). Similarly, a statistically significant
increase in right rectus femoris muscle stiffness was detected in the BFR-RE group (p < 0.05,
BF10 > 1) but not in the HL-RE group (p > 0.05, BF10 < 1). Furthermore, time’s main effect
was statistically insignificant for thigh circumference (p > 0.05, BFincl < 1). The group ×
time interaction was statistically significant only for peak power leg flexion left (p < 0.05,
BFincl > 1), and a statistically significant difference in favor of the BFR-RE group was
observed in the intergroup comparisons (p < 0.05, BF10 > 1). Conclusions: In conclusion,
BF-RE exercise with voluntary exhaustion may be as effective as HL-RE for hypertrophic
adaptations in untrained young males.
