Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS

Basit Öğe Kaydı
dc.contributor.authorMutlu, Muzaffer
dc.contributor.authorBingöl, Zeynebe
dc.contributor.authorÖzden, Eda Mehtap
dc.contributor.authorKöksal, Ekrem
dc.contributor.authorErtürk, Adem
dc.contributor.authorGören, Ahmet C.
dc.contributor.authorAlwasel, Saleh
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2025-08-12T08:36:02Z
dc.date.available2025-08-12T08:36:02Z
dc.date.issued2025
dc.departmentİstanbul Gelişim Meslek Yüksekokulu
dc.description.abstractBackground: In this study, the antioxidant and anti-Alzheimer’s disease properties of Chia (Salvia hispanica) seed oil (CSO) were determined for the first time. Three different metal reduction and two different radical scavenging methods were used to determine the antioxidant properties of CSO. It exhibited higher antioxidant activity than vitamins E and C in the CUPRAC method. Results: CSO has shown excellent efficacy in the antioxidant methods used in this study. In the DPPH radical scavenging method, CSO exhibited higher radical scavenging potential than BHT, a standard and synthetic antioxidant. The anti-Alzheimer’s disease properties of CSO were determined by inhibition of acetylcholinesterase enzyme and its IC50 value (17.60 lg/mL) was found to be close to the IC50 value of tacrine (8.82 lg/mL), the standard inhibitor of the enzyme. Inhibition properties of a-glycosidase enzyme and human carbonic anhydrase II isoenzymes were also studied. It was understood that CSO inhibited both enzymes at a lower rate than standard inhibitors. Also, the total phenolic and flavonoid contents of CSO were determined as 784.44 lg gallic acid equivalent (GAE)/mL oil and quercetin 150.00 lg QE)/mL oil, respectively. In addition, LC-HRMS chromatography application was performed to understand the phenolic content of CSO. It was determined that isosakuranetin (29.07 mg/L oil) was the most abundant polyphenolic compound in CSA. Also, seven polyphenolics of the studied remained below the detectable amount. Conclusions: It was found that CSO had effective antioxidant activity, polyphenolic contents and potent enzyme inhibition properties, associated with some global disease.
dc.identifier.citationMutlu M, Bingol Z, Ozden EM, et al. Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS. Electron J Biotechnol 2025;74. https://doi.org/10.1016/j.ejbt.2024.12.002.
dc.identifier.doihttps://doi.org/10.1016/j.ejbt.2024.12.002
dc.identifier.endpage53
dc.identifier.issn0717-3458
dc.identifier.startpage41
dc.identifier.urihttps://hdl.handle.net/11363/10258
dc.identifier.volume74
dc.identifier.wos001443415200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.institutionauthorMutlu, Muzaffer
dc.language.isoen
dc.publisherPONTIFICIA UNIV CATOLICA VALPARAISO, AV BRASIL 2950, PO BOX 4059, VALPARAISO 0000, CHILE
dc.relation.ispartofELECTRONIC JOURNAL OF BIOTECHNOLOGY
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-Alzheimer properties
dc.subjectAntioxidant activity
dc.subjectAntioxidant
dc.subjectChia
dc.subjectEnzyme inhibition
dc.subjectLC-HRMS
dc.subjectPhytochemical screening
dc.subjectPolyphenols
dc.subjectSalvia hispanica
dc.subjectSeed oil
dc.titleAntioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale / Article
Boyut:
533.3 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Web of Science ve Scopus Atıf Dizinlerindeki Yayınlar
WoS İndeksli Yayınlar Koleksiyonu