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    Isocoumarins and 3,4-dihydroisocoumarins, amazing natural products: a review
    (TÜBİTAK, 2017) Saddiqa, Aisha; Usman, Muhammad; Çakmak, Osman
    The isocoumarins are naturally occurring lactones that constitute an important class of natural products exhibiting an array of biological activities. A wide variety of these lactones have been isolated from natural sources and, due to their remarkable bioactivities and structural diversity, great attention has been focused on their synthesis. This review article focuses on their structural diversity, biological applications, and commonly used synthetic modes.
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    Reinvestigation of bromination of 8-substituted quinolines and synthesis of novel phthalonitriles
    (Acg Publications, 2016) Okten, Salih; Cakmak, Osman; Saddiqa, Aisha; Keskin, Bahadir; Ozdemir, Seda; Inal, Merve
    Bromination of a series of 8-substituted quinolines was reinvestigated and specified for optimum yields and isolation conditions. Mono bromination of 8-hydroxyquinoline (2a) and 8-aminoquinoline (2c) gave mixture of mono and dibromo derivatives 5,7-dibromo-8-hydroxyquinoline (3a), 5,7-dibromo-8aminoquinoline (3c), 7-bromo-8-hydroxyquinoline (3d), 5-bromo-8-aminoquinoline (3e) while 8methoxyquinoline (2b) furnished 5-bromo-8-methoxyquinoline (3f) as sole product. Novel phthalonitriles, 4(quinolin-8-yloxy) phthalonitrile (6) and 4-chloro-5-(quinolin-8-yloxy) phthalonitrile (8) of 8-hydroxyquinoline (2a) were synthesized and converted into their respective bromo derivatives 4-(5-bromoquinolin-8yloxy) phthalonitrile (7) and 4-((5-bromoquinolin-8-yl) oxy)-5-chlorophthalonitrile (9).