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    Effects of Local Application of Nano-silver on Osteomyelitis and Soft Tissue Infections: An Experimental Study in Rats
    (Copernicus GmbH, 2018) Kemah, Bahattin; Uzer, Gökçer; Turhan, Yalçln; Özturan, Burak; Klllç, Bülent; Gültepe, Bilge Sümbül; Ceyran, Ayşe Bahar
    Bone and soft tissue infections are among the least desired complications after orthopaedic surgery. This study analysed the effects of the local application of nano-silver particles (AgNPs) [1nm Combining double low line 1 billionth of a meter] in soft tissue infections. Materials-Method An experimental osteomyelitis model was formed by inoculating both tibias of 24 rats with methicillin-resistant. The rats were followed without treatment for 21 days. Blood samples and tibial x-rays at day 21 confirmed the development of infection. Then, the rats were divided randomly into two groups. One group (12 rats) underwent surgical debridement and received 21 days of teicoplanin therapy. The second group had the same treatment, with the addition of local nano-silver. All of the rats were sacrificed at day 42. Blood and wound swab samples were taken and the culture results were analysed. No differences were observed between the groups in healing values at pathological examination, or in changes in the number of colonies at days 21 and 42. No differences in white blood cell count (WBC) were observed between the groups before and after the treatment. idCombining double low line Although studies suggest the effectiveness of AgNPs on pathogens, we found that the application of nano-silver did not make any difference when used in addition to the classical osteomyelitis treatment with antibiotics and local surgical debridement. We believe that additional studies using repeated nano-silver application could be beneficial. © 2022 Geosci. Model Dev. All rights reserved.
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    Endometrial Adenocarcinoma Recurrence Presenting With Tibial Metastasis: Report of a Case
    (Elsevier B.V., 2017-04-18) Söylemez, Mehmet Salih; Kemah, Bahattin; Söylemez, Umut Perçem Orhan; Kılıç, Bülent; Özkan, Korhan
    Introduction: Metastatic bone disease at extremities is mostly associated with lung, liver, prostat, thyriod or breast malignancies. There for surgeons generally tends to seek for a primary tumor originating from these organs. Herein a case of endometrial adenocarcinoma recurrence that presented with symptoms of tibial pain is described. Presentation of case: 59 year-old woman was admitted to our orthopaedic oncology unit with pain, swelling and tenderness at right cruris for two weeks without any trauma history. Her medical history revealed that she had a total abdominal hysterectomy and bilateral salpingo-oophorectomy. During follow-ups no recurrence had been detected. Initial X-rays of the right tibia showed a lytic and expansile mass located at the shaft of the tibia suggesting metastasis. A wide resection of the lesion with clear margins was performed two weeks after first admittance. Resected area was replaced by fresh frozen femoral shaft allograft. At postoperative 17th month. X-rays obtained at last follow-up demostrated full healing and integration of allograft. Discussion: Endometrial adenocarcinoma is a disease of postmenapousal women with 95% of the cases occurring after the age of 40 years. Patients with advanced or recurrent endometrial cancer often have distant metastases found within the lymph nodes, liver, and/or lung. Conclusion: Recurrence of endometrial cancer as a solitary bone lesion is a rare situation. Wide resection and reconstruction with an allograft or an intercalar prosthesis might be an option to increase survival and possible cure of the patient.
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    An Unusual Orthopaedic Disease: Sarcoidosis—A Case Report
    (Thieme Medical Publishers, 2017-02-23) Kemah, Bahattin; Özturan, Burak; Bilgiç, Bilge; Özkan, Korhan; Akpınar, Fuat; Kılıç, Bülent
    Sarcoidosis is an idiopathic, noncaseating granulomatous disorder with wide systemic involvement. It is encountered widely around the world and it affects both sexes, all the races in all age groups. Lungs, eyes, and skin are the organs most commonly affected. Constitutional features such as weight loss, fatigue, and myalgia are the most common symptoms. Bone involvement, which is very rare, was reported as present in 3 to 13% of effected cases, and it is most commonly seen in hands and feet, compared with long bone involvement, which is extremely rare. We hereby present a case with a diagnosis of sarcoidosis and multiple bone involvement emphasizing the importance of differential diagnosis.