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3D-printed polylactic acid (PLA)/polymethyl silsesquioxane (PMSQ)-based scaffolds coated with vitamin E microparticles for the application of wound healing
(Springernature, 2024) Anjrini, Nasma; Karabulut, Hatice; Ulag, Songul; Ege, Hasan; Noberi, Cansu; Dogan, Ecem; Sahin, Ali
Skin is part of the integumentary and excretory system, which helps protect the body against infections. The skin should be properly treated when it gets injured, which requires a long healing process. In this study, 15% (w/v) polylactic acid (PLA) and 1 and 2% (w/v) polymethylsilsesquioxane (PMSQ) scaffolds were fabricated using 3D printing technology, and the surfaces of each scaffold were coated with 5% ethylcellulose (EC)/vitamin E microparticles using the electrospray method. The morphologies of the scaffolds were characterized using a scanning electron microscope (SEM), and results showed that the pore sizes of the scaffolds ranged from 136 to 265 mu m. The vitamin E was completely released from the scaffolds within 5 h. MTT test was performed with fibroblast cells and results proved the biocompatibility of the scaffolds. These findings showed that the scaffolds may have good potential as a wound dressing material. The biodegradation test was performed in in vitro conditions and results showed that the surface coating with 5% EC/vitamin E microparticles on the 15% PLA/2% PMSQ scaffolds increased the degradation rate of the scaffolds.