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Öğe Association of the attachment styles with depression, anxiety, and quality of life in patients with psoriasis(WOLTERS KLUWER MEDKNOW PUBLICATIONS, WOLTERS KLUWER INDIA PVT LTD, A-202, 2ND FLR, QUBE, C T S NO 1498A-2 VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra 400059, INDIA, 2020) Demirci, Onur Okan; Ateş, Bilge; Sağaltıcı, Eser; Ocak, Zehra Gizem; Kıvanç Altunay, İlknurObjectives: This is a cross-sectional study to investigate the attachment styles and their impact on depression, anxiety, and quality of life in people with psoriasis. Methods: All participants completed socio-demographic and illness specific questionnaires along with Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS) and Adult Attachment Style Scale (AASS). 100 individuals with psoriasis and 130 individuals with no dermatological problems participated in the study. Results: HADS scores for depression (38% versus 15.4%, P < .001) and anxiety (28% versus 6.9%, P < .001) were higher in participants with psoriasis compared to the healthy participants in the control group. AASS scores of participants for anxious/ambivalent attachment (13.7±4.0 versus 13.3±3.9, P = .465), secure attachment (15.8±4.4 versus 16.2±3.9, p = .510), and avoidant attachment (11.0±3.6 versus 11.3±3.6, P = .598) did not differ significantly in two groups. There was a significant correlation between DLQI scores and anxious/ambivalent attachment scores of participants with psoriasis (P < .05, r = .222). HADS scores of participants with psoriasis were also found significantly correlated with insecure attachment styles; anxious/ambivalent attachment (depression, P < .001/ anxiety, P < .001), avoidant attachment (depression, p < .001/ anxiety, p < .01). Conclusion: This study demonstrates that there is a relationship between the insecure attachment styles and depression, anxiety and reduced quality of life in people with psoriasis and also support the idea that attachment insecurities can impair the physiological stress response by increasing the perceived stress in these patients.Öğe Associations of dysfunctional attitudes, ruminations and metacognitive beliefs about rumination with pharmacological treatment response in patients with first episode of major depression(TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, 2023) Özben, İlker; Şenormancı, Güliz; Demirci, Onur Okan; Şenormancı, ÖmerIntroduction: The aim of this study is to investigate whether treatment with selective serotonin reuptake inhibitors (SSRI) has an effect on the ruminative response, ruminative beliefs and dysfunctional attitudes (DA), and to evaluate the effects of pre-treatment dysfunctional attitudes and rumination levels on treatment response in individuals diagnosed with the first episode of major depression (MD). Methods: 110 patients with MD participated in this study. Participants were evaluated with the Hamilton Depression Rating Scale (HDRS), the Clinical Global Impression Scale (CGI), the Short Version of Ruminative Response Scale (RRS), the Positive Beliefs about Rumination Scale (PBRS), the Negative Beliefs about Rumination Scale (NBRS), and the Dysfunctional Attitude Scale form A (DAS-A) before receiving SSRI treatment and 2 months after the onset of treatment. Results: After two months of SSRI treatment, patients were divided into two groups, remission and nonremission groups. The decrease in RRS subscales and total scores, NBRS uncontrollability and danger of ruminations score, PBRS total score and DAS-A autonomous attitude scores were significantly higher in the remission group. RRS and DAS-A scores were found to be predictors of remission. Conclusions: DA and ruminations may be associated with poor response to SSRI treatment in depression.Öğe Bilişsel Esnekliğin Bilişsel Duygu Düzenleme Üzerindeki Etkisi(Bursa Uludağ Üniversitesi, 2020) Demirci, Onur Okan; Güneri Yöyen, ElifBilişsel esnekliğin bilişsel duygu düzenleme üzerindeki etkisinin incelendiği çalışmanın verileri öğrenim görmekte olan 300 üniversite katılımcısından elde edilmiştir. Bilişsel Esneklik Envanteri, Bilişsel Duygu Düzenleme Ölçeği ve Sosyodemografik Veri Formu kullanılmıştır. Çalışma sonucunda; bilişsel esneklikte “alternatif” düzeyinin, bilişsel duygu düzenlemede “diğerlerini suçlama”, “felaketleştirme”, “olumlu yeniden odaklanma”, “plan yapmaya yeniden odaklanma”, “olumlu yeniden değerlendirme” ile pozitif; “kendini suçlama” ve “ruminasyon” düzeylerini negatif yordadığı görülmektedir. Bilişsel esneklikte “kontrol” düzeyinin, bilişsel duygu düzenlemede “kendini suçlama”, “diğerlerini suçlama” düzeylerinin pozitif; “ruminasyon”, “olumlu yeniden odaklanma” ve “plan yapmaya yeniden odaklanma” boyutlarını ise negatif yordadığı görülmektedir. Ek olarak bilişsel duygu düzenlemede kadınların erkeklere göre daha yüksek düzeyde “diğerlerini suçlama” eğilimi gösterirken, erkeklerde kadınlara göre daha yüksek “felaketleştirme” eğilimi görülürken, bilişsel esneklik kadınlar ve erkeklerde bir farklılık göstermemektedir. Bilişsel esneklik ve bilişsel duygu düzenlemede yaş faktörü anlamlı bir farklılık oluşturmamıştır.Öğe Comparison of Eye Movement Desensitization and Reprocessing (EMDR) and Duloxetine Treatment Outcomes in Women Patients with Somatic Symptom Disorder(Kure Iletisim Grubu A.S., 2017) Demirci, Onur Okan; Sa?altici, Eser; Yildirim, Abdullah; Boysan, MuratSomatic symptom disorder (SSD) is a debilitating disorder that significantly diminishes quality of life and causes psychological distress such as anxiety and depression. The paper explored the efficiency of the eye movement desensitization and reprocessing (EMDR) therapy in SSD. The current investigation is a clinical trial investigating the effectiveness of eye movement desensitization (EMDR) therapy in the treatment of 31 first-diagnosed SSD patients in comparison to age, education and marital status matched 31-first-diagnosed SSD patients who received duloxetine over a 6-week course of treatment. Somatization subscale of the Symptom Checklist-Revised 90 (SCL-90), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Short Form Health Survey (SF-36) were administered to the participants. EMDR group showed enhanced improvement relative to baseline after 6 weeks of treatment compared to duloxetine group. We concluded that EMDR appears to be a highly promising therapy and should be considered among the first-line interventions in the treatment of SSD.Öğe Comparison of pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1) gene polymorphisms among patients with methamphetamine addiction, methamphetamine-induced psychosis and healthy controls(Masson Editeur, 2023) Turan, Cetin; Senormanci, Guliz; Senormanci, Omer; Celik, Sevim Karakas; Cakmak, Gunes; Demirci, Onur OkanObjective. - Recent studies have shown the role of the PACAPergic system in addiction and psychotic disorders. Studies also show the close association of methamphetamine with psychosis. In our study, we aim to compare the distribution of PACAP rs2856966, rs2231181, and rs1610037 gene polymorphisms, as determined according to literature research, among the patients with methamphetamine addiction (MA), patients with methamphetamine-induced psychosis (MIP), and healthy controls (HC), and to investigate the associations of these polymorphisms with MA and MIP.Methods. - In all, 173 patients diagnosed with MA, 120 patients diagnosed with MIP, and 104 HC without any history of substance abuse were included. Inter-group PACAP rs2856966, rs2231181, and rs1610037 genotypes were examined.Results. - The rs2231181 CC genotype was determined to increase the risk of MA by 2708 times (13 = 2708, P = 0.010) and the risk of MIP by 2786 times (13 = 2786, P = 0.010). The rs1610037 GG genotype was observed to increase the risk of MA by 9322 times (13 = 9322, P < 0.001) and the risk of MIP by 6579 times (13 = 6579, P = 0.004). Conclusion. - Through the PACAPergic system, new treatment interventions specific to MIP and for reducing relapses in MA can be developed. Moreover, treatments to be developed through the PACAPergic system may also be beneficial in preventing the neurotoxicity caused by methamphetamine, by the effect of PACAP on neural development.(c) 2023 Elsevier Masson SAS. All rights reserved.Öğe The effect of psychopathology on quality of life and disability in patients with fibromyalgia(Prusa Medikal Yayıncılık Limited Şirketi, 2022) Akay, Esra; Şenormancı, Ömer; Eröksüz, Rıza; Şenormancı, Güliz; Demirci, Onur OkanObjectives: The aim of the study was to investigate the relationship between pain, depression, anxiety, somatic amplification and alexithymia in patients with fibromyalgia syndrome (FMS), and on quality of life and disability. As a secondary goal, the predictors of disability were evaluated. Methods: Participants were 112 female patients aged 18 and over, applied to the outpatient clinic of University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital Medical Ecology and Hydroclimatology department and diagnosed with FMS according to ACR 2016 Revised Fibromyalgia Diagnosis Criteria. The Sociodemographic Data Form, Visual Analog Scale (VAS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Toronto Alexithymia Scale (TAS-20), Somatosensory Amplification Scale (SSAS), Fibromyalgia Impact Questionnaire (FIQ) and Health Survey Questionnaire Short Form (SF36) were applied to each participant. All data were analyzed with correlation and linear regression. Results: Increased pain intensity, depression, anxiety, somatic amplification, "difficulty identifying feeling" and "difficulty describing feelings" dimensions of alexithymia were found related to lower quality of life and increased disability. Depression, somatic amplification, and pain severity were defined as the predictors of disability in FMS. Conclusions: Psychiatric examination of FMS patients especially in terms of depression, anxiety, alexithymia and somatic amplification as well as their physical complaints can be beneficial to minimize disability and increase the quality of life. To our best knowledge, this is the first study to show somatic amplification as a predictor of disability in FMS patients. Further studies will be helpful to understand this relationship.Öğe Ergoterapi: Geleceğin Mesleği Olabilecek Bir Meslek Alanı(KLINIK PSIKIYATRI DERGISI, STRAZBURG CAD 4-11 SIHHIYE, ANKARA 00000, TURKEY, 2017) Demirci, Onur Okan‘Ergo’ kelimesi Yunanca kökenli olup ‘iş’ anlamına gelmektedir. Ruhsal veya fiziksel engeli bulunan bireyleri duruma yönelik aktivitelerle yeniden topluma kazandırmak amacıyla uygulanan bir yöntemdir. Ergoterapi, bir diğer adı ile uğraşı terapisi, bünyesinde sanat, müzik, resim, el işi, fiziksel aktiviteler, motor-fonksiyon terapisi, duyumsal algı sağlama egzersizleri, yaşamı idame ettirebilme egzersizleri gibi bir çok etkinliği barındırmaktadır. Bir çok insan ergoterapiyi yeni bir sağlık alanı olarak düşünebilir fakat tarihi oldukça eskidir. Milattan sonra 4. Yüzyılda Bergamada Asklepios tapınağında şifalı su, çamur banyoları, spor ve tiyatro etkinliklerinin engelli kişilerin rehabilitasyonunda kullanıldığı bilinmektedir. Ergoterapinin günümüzde etkinliğine dair giderek artan sayıda bilimsel makale yayınlanmaya devam etmektedir. Amerika Birleşik Devletleri’ nde ergoterapi en iyi sağlık meslekleri arasında 17. sırada yer alırken, tüm meslekler içinde en iyi meslekler sıralamasında 23. sırada yer almaktadır. Günümüzde dünyada bir çok alanda çalışan ergoterapistler bulunmakta iken ne yazık ki ülkemizde bu sayı çok kısıtlıdır. Bu anlamda ergoterapi, yakın gelecekte Türkiye’ de önemli bir iş alanı olacak gibi görünmektedir.Öğe Evaluation of Paraoxonase, Arylesterase, Dipeptidyl Peptidase-IV, Oxidative Stress, and Oxidative DNA Damage in Patients with Obsessive-Compulsive Disorder(Maik Nauka/Interperiodica/Springer, 2024) Sağaltıcı, Eser; Belli, Hasan; Kırankaya, Ayşegül; Köse, Hüseyin; Ural, Cenk; Namli, Mustafa Nuray; Demirci, Onur OkanSome findings have emerged from the field of oxidative stress in patients with psychiatric disorders. These date also state that oxidative balance and obsessive-compulsive disorder (OCD) are significantly related. Yet, researchers have not investigated oxidative stress, oxidative balance, and DNA damage together. We tested the levels of paraoxonase-1 (PON1), and arylesterase (ARE). We also tested the dipeptidyl peptidase-IV (DPP-IV), oxidative stress, and oxidative DNA damage. We enrolled 37 patients with OCD in the study. The diagnosis of OCD according to DSM-V criteria was established. Patients had not received treatment for at least 6 months. The controls were matched with the patients about sex, age, body mass index (BMI), and smoking. Clinicians used the sociodemographic information form. All subjects were evaluated with a semi-structured questionnaire. Serum PON1, ARE, DPP-IV, oxidative stress index (OSI), and 8-hydroxideoxiguanosine (8-OHdG) calculations were conducted in the biochemical laboratory. PON1 and DPP-IV levels were not different between OCD patients and the control group (P > 0.05). An oxidative DNA damage marker 8-OHdG-and OSI were higher in the patient's group (p < 0.05). But levels of ARE were significantly lower in OCD patients (P < 0.05). We found evidence that oxidative stress-induced parameters such as OSI, ARE, and 8-OHdG might be related to a specific pathologic state in patients with OCD. The findings may provide a rationale for treating the pathological processes.Öğe Eye Movement Desensitization and Reprocessing (EMDR) Treatment in Social Anxiety Disorder: A Case Report(MEDICINSKA NAKLADA, VLASKA 69, HR-10000 ZAGREB, CROATIA, 2019) Sağaltıcı, Eser; Demirci, Onur OkanEYE MOVEMENT DESENSITIZATION AND REPROCESSING (EMDR) TREATMENT IN SOCIAL ANXIETY DISORDER: A CASE REPORTÖğe Is there a relationship between childhood traumatic experiences, somatoform dissociation, and subjective tinnitus?(BAYRAKOL MEDICAL PUBLISHER, EMRAH MAHALLESI, GULGUN CADDESI, NO 62-58, KEÇİÖREN, ANKARA 06010, TURKEY, 2022) Sağaltıcı, Eser; Belli, Hasan; Belli, Şeyda; Şentürk, Erman; Demirci, Onur OkanAim: This study aimed to reveal the existence of childhood traumatic experiences representing the symptoms of somatoform dissociation in patients with subjective tinnitus. Material and Methods: One hundred forty patients with cases of tinnitus for more than six months and 118 healthy volunteers between the ages of 18 and 35 were admitted. Researchers employed the Childhood Trauma Questionnaire (CTQ), Somatoform Dissociation Questionnaire (SDQ), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) in cases with tinnitus and control subjects, and Tinnitus Handicap Inventory (THI) solely in the tinnitus group. Results: We found very high levels of emotional abuse, physical abuse, sexual abuse, emotional neglect, physical neglect, SDQ, BDI, and BAI in patients with subjective tinnitus. However, there was a statistically significant positive correlation between SDQ and THI. When patients with tinnitus were separated using the SDQ cutoff score, very high levels of emotional abuse, physical abuse, emotional neglect, and physical neglect were found in patients with SDQ ? 35 scores. We also found the high-level THI predicted the SDQ. Discussion: We have determined that tinnitus is associated with a strong effect to integrate childhood traumatic experiences and somatoform dissociation. Trauma-oriented psychotherapies may be useful for patients with subjective tinnitus to manage trauma-related symptoms.Öğe Psikojenik Pruritus ve Buna Bağlı Erektil Disfonksiyon Tedavisinde Mirtazapin Kullanımı: İki Olgu Sunumu(ANP Sağlık Hizmetleri Yayınevi San. ve Tic. Ltd. Şti., 2016) Demirci, Onur Okan; Çeçen, Hülya; Çinik, EmrahPatolojik kaşıntı nedenleri oldukça fazla olmakla birlikte sadece ruhsal nedenlere bağlı ise psikojenik pruritus olarak adlandırılır. Fransız Psikodermatoloji Grubu, psikojenik pruritus tanımı yerine ‘fonksiyonel kaşıntı bozukluğu’ denmesini uygun görmektedir. Erektil disfonsiyon, Diagnostic Statistical Manual-5’ te cinsel işlev bozuklukları ana başlığı altında sınıflandırılmaktadır. Erektil disfonsiyonun dünyadaki en sık nedeni psikojenik faktörlerdir. Bu yazıda, psikojenik pruritus başlangıcı sonrası erektil disfonksiyon gelişen 2 olgunun mirtazapin ile tedavisinin sonuçlarını tartışmayı amaçladık. Metod. Hastalara tedavi öncesi ve tedavinin 12. haftasında olmak üzere ikişer kez Beck anksiyete ölçeği, Beck Depresyon Ölçeği ve Arizona cinsel yaşantılar ölçeği uygulandı. Sonuç. Mirtazapin ile sürdürülen tedavinin 12. haftasında erektil disfonksiyonda belirgin iyileşme ve ölçek skorlarında anlamlı azalma gözlemlenmiştir.Öğe Telemental health care provides much-needed support to refugees(Nature Portfolio, 2022) Nielsen, Selin Yildiz; Sagaltici, Eser; Demirci, Onur Okan[Abstract Not Available]
