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    CLINICAL UTILITY OF TENSIN 2 LEVELS AS A DIAGNOSTIC AND PROGNOSTIC BIOMARKER IN BREAST CANCER
    (Carbone Editore, 2021) Serin, Kursat Rahmi; Ucuncu, Zubeyr; Temel, M. Kemal; Bademler, Suleyman; Soydinc, Hilal Oguz; Karanlik, Hasan; Karabulut, Senem
    Background: To discuss the diagnostic and prognostic potential of tensin-2 (TNS2) levels in patients with breast cancer (BC). Methods: The study included sixty patients with BC and twenty healthy female controls for a comparative investigation of TNS2 protein and gene expression levels.. Results: Compared to the healthy controls, we found that the patient group showed a statistically significantly lower mean level of TNS2 protein (p<0.001) and higher mean level of TNS2 gene expression (p=0.015). Secondly, we examined the clinical utility of TNS2 levels as an indicator of invasiveness and aggressiveness in BC by comparing patient TNS2 levels by stage and grade. Although the measured mean values differed between the patients subgrouped by tumor biology, grade, and stage, we found that the differences were not statistically significant. Conclusion: Our findings suggest that TNS2 levels can be utilized diagnostically and prognostically, and that there is a need for further studies with larger he mean values measured differed between the patient subgroups based on tumor elucidate the clinical value of TNS2 protein and gene expression levels as an early prognosticator of aggressiveness in BC and thus a useful criterion in treatment optimization.
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    ROLE OF INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3) IN THE DIAGNOSIS OF PANCREATIC ADENOCARCINOMA AND MONITORING TREATMENT RESPONSE
    (Carbone Editore, 2019) Bademler, Suleyman; Ucuncu, Whammed Zubeyr; Sari, Murat; Yasasever, Ceren Tilgen; Afsar, Cigdem Usul; Tastekin, Didem
    Purpose: Pancreatic cancer occurs rarely in humans, and it is one of the most fatal five cancer types with very poor prognosis. Early diagnosis of pancreatic cancer is difficult due to late presentation of symptoms. The purpose of our study was to evaluate the utility of IGFBP-3 and IGF-1 in early diagnosis of pancreatic cancer and in monitoring treatment response and contribute to the studies conducted in this regard. Methods: The study included 108 subjects, 54 of who were diagnosed with and followed-up for pancreatic cancer and 54 were healthy subjects. The results were compared between the two groups. The study was approved by the Istanbul Faculty of Medicine Ethics Committee. Results: The mean age of the patients included in the study was 54.42 years. IGF-1 levels and IGFBP-3 levels were significantly lower in pancreatic cancer patients than in the control group (respectively p = 0.002, 0.004). There was no difference between IGF-1 and IGFBP-3 levels in patients with distant metastasis (p > 0.05). IGF- 1 levels were significantly higher in patients who responded to chemotherapy than in those who did not respond to chemotherapy (p = 0.03). Conclusions: In our study, we observed that IGF-1 and IGHIP-3 levels can be used for the diagnosis of patients with pancreatic cancer and evaluation of treatment response and prognosis, and there is no significant difference in serum levels according to age, presence of distant metastasis, and gender.
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    Öğe
    Standardized Laparoscopic Sphincter-preserving Total Mesorectal Excision For Rectal Cancer: Median of 10 Years' Long-term Oncologic Outcome in 217 Unselected Consecutive Patients
    (Lippincott Williams & Wilkins, 2019) Bademler, Suleyman; Koza, Kadir B.; Ucuncu, Muhammed Z.; Tokmak, Handan; Bakir, Baris; Oral, Ethem N.; Asoglu, Oktar
    This study was designed to evaluate the impact of a standardized laparoscopic total mesorectal excision (TME) on the long-term oncologic outcome. Unselected consecutive patients with rectal cancer underwent a standardized laparoscopic TME with medial to lateral approach encompassing 9 sequential steps. From 2005 to June 2012, laparoscopic sphincter-preserving TME was attempted in 217 patients. Mean follow-up of all patients was a median of 91 months (range, 3 to 164 mo). The local recurrence rate was 6.5%, and the distant recurrence rate was 19.8%. The 10-year disease-free survival (DFS) rates were 76.4% and overall survival (OS) was 67.1%. In the converted group, DFS and OS were 50% and 46.7%, respectively. In the laparoscopic group, DFS and OS were 78.3% and 68.5%, respectively. A standardized laparoscopic sphincter-preserving TME resulted in a favorable long-term oncologic outcome in unselected patients with rectal cancer. Conversion to open surgery has impaired OS and DFS.