Yazar "Ak, Esin" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Assessing the protective effects of chard on valproic acid-induced pancreatic complications
    (NATL INST SCIENCE COMMUNICATION-NISCAIR, DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA, 2024) Alev Tüzüner, Burçin; Ak, Esin; Tunalı, Sevim; İpekci, Hazal; Üstundağ, Ünsal Veli; Tunalı Akbay, Tuğba; Emekli Alturfan, Ebru; Çetinel, Şule; Yanardağ, Refiye; Yarat, Ayşen; Ahmad, Sarfraz
    Valproic acid (VPA) treatment is known to potentially cause adverse effects, notably as the most common cause of druginduced acute pancreatitis. It is crucial to balance the therapeutic benefits and potential major side effects of VPA administration. Complications associated with VPA may arise from toxic VPA metabolites and alterations in antioxidant levels. While chard is well-known for its anti-hyperglycemic and antioxidant properties, there is a lack of research on its impact on the pancreas during VPA treatment. This study aimed to explore the possible protective effects of chard against VPA-induced complications in the pancreas using histological and biochemical approaches. Animals were separated into four groups: i) Control, ii) received chard (100 mg/kg), iii) received VPA (500 mg/kg), and iv) received VPA+Chard (in the same dosages and time). On the eighth day, the rats’ pancreatic tissue and blood specimens were collected. In the Chard and VPA+Chard groups, chard decreased blood glucose levels compared to the control and VPA groups. In comparison to the VPA group, the VPA+Chard group pancreatic glutathione level and catalase activity increased whereas malondialdehyde levels decreased. Furthermore, administration of chard to the control and VPA groups increased tissue factor activity and sialic acid level as compared to the VPA group. The histological findings confirmed the biochemical results. It is therefore concluded that chard has the potential to protect pancreatic tissue from VPA-induced complications by reducing lipid peroxidation and blood glucose while enhancing antioxidants and sialic acid levels.
  • Küçük Resim
    Öğe
    Biochemical and Histological Analysis of Collagen Content in Lung, Liver and Kidney Tissues of Rats Treated With Beta Vulgaris L. Var. Cicla
    (Kocaeli Üniversitesi, 2025) Alev Tüzüner, Burçin; Muhan, Aleyna; Oktay, Sehkar; Ak, Esin; Tunalı, Sevim; Yanardağ, Refiye; Yarat, Ayşen
    Objective: Collagen is a fundamental component of the extracellular matrix (ECM) and plays a critical role in organ structure, cellular functions, and wound healing. Beta vulgaris L. var. cicla (chard) is known for its diverse bioactive compounds, including vitamins, flavonoids, and nitrates. Chard has been associated with numerous health benefits, such as antioxidant, anti-inflammatory, and antidiabetic effects. This study investigates the impact of chard on collagen content in vital organs, specifically the lung, liver, and kidney. Methods: The rats divided into two groups: the control and the chard given group. The chard extract was administered to rats at a dose of 100 mg/kg per day for 7 days. On the 8th day, the rats were sacrificed, and tissues from the lung, kidney, and liver were collected. The collagen content was measured using both biochemical and histological analyses. Results: Chard administration exhibited tissue-specific effects on collagen content: it increased collagen in the lung, decreased it in the liver significantly, and had no effect on kidney collagen. These biochemical changes were supported by histological results in the lung and kidney; however, no significant histological changes were observed in the liver. These varied effects might be related to differences in collagen metabolism and regulatory mechanisms across tissues. Conclusion: The findings suggest that chard, due to its distinct effects on collagen synthesis and ECM remodeling, holds promise as a potential therapeutic agent for applications such as wound healing, tissue strengthening, and antifibrotic therapy. Further studies on the mechanisms underlying these effects are necessary to fully understand the potential of chard in clinical applications.