dc.contributor.author | Karamanlıoğlu, Mehlika | |
dc.contributor.author | Yeşilkır Baydar, Serap | |
dc.date.accessioned | 2024-03-13T23:31:06Z | |
dc.date.available | 2024-03-13T23:31:06Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.issn | 0920-5063 | |
dc.identifier.issn | 1568-5624 | |
dc.identifier.uri | https://hdl.handle.net/11363/7202 | |
dc.description.abstract | This study determined the influence and ideal ratios of various
coconut oil (CO) amounts in gelatin (G) based-films as wound
dressings since there are limited comparative studies to evaluate
the sole effect of increasing CO on protein-based biomaterials.
Homogenous films at G:CO ratio of 4:0,4:2,4:3,4:4 (w:w) corresponding to CO-0, CO-2, CO-3, CO-4, respectively, were obtained using
solution casting. SEM showed CO caused rougher surfaces decreasing mechanical strength. However, no pores were observed in
CO-4 due to bigger clusters of oil improving stretchability compared to CO-3; and durability since aging of CO-4 was >10% lower
than CO-0 in aqueous media. FTIR showed triglycerides’ band only
in CO films with increasing amplitude. Moreover, amide-I of CO-2
was involved in more hydrogen bonding, therefore, CO-2 had the
highest melt-like transition temperatures (Tmax) at ~163°C while
others’ were at ~133°C; and had more ideal mechanical properties
among CO films. XTT showed that increased CO improved 3T3 cell
viability as CO-0 significantly decreased viability at 10,50,75,100μg/
mL (p<0.05), whereas CO-2 and CO-3 within 5-75μg/mL and CO-4
within 5-100μg/mL range increased viability ≥100% suggesting
proliferation. All CO samples at 25μg/mL stimulated 3T3 cell migration in Scratch Assay indicating wound healing. CO amounts mainly
improved thermal and healing properties of gelatin-based biomaterial. CO-2 was more thermally stable and CO-4 had better influence on cell viability and wound healing than CO-0. Therefore,
increased CO ratios, specifically 4:2 and 4:4, G:CO (w:w), in
gelatin-based films can be ideal candidates for wound dressing
materials. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS LTD2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND | en_US |
dc.relation.isversionof | 10.1080/09205063.2023.2265624 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Coconut oil | en_US |
dc.subject | gelatin | en_US |
dc.subject | wound dressing | en_US |
dc.subject | wound healing | en_US |
dc.subject | 3T3 | en_US |
dc.subject | cytotoxicity | en_US |
dc.title | Characterization of gelatin-based wound dressing biomaterials containing increasing coconut oil concentrations | en_US |
dc.type | article | en_US |
dc.relation.ispartof | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | en_US |
dc.department | Mühendislik ve Mimarlık Fakültesi | en_US |
dc.authorid | https://orcid.org/0000-0002-4814-6346 | en_US |
dc.authorid | https://orcid.org/0000-0001-6311-4302 | en_US |
dc.identifier.volume | 35 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 16 | en_US |
dc.identifier.endpage | 44 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.institutionauthor | Karamanlıoğlu, Mehlika | |
dc.contributor.institutionauthor | Yeşilkır Baydar, Serap | |