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dc.contributor.authorAlev Tüzüner, Burçin
dc.contributor.authorGenç Kahraman, Nevin
dc.contributor.authorİpekçi, Hazal
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorTunalı Akbay, Tuğba
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorŞener, Göksel
dc.contributor.authorYarat, Aysen
dc.date.accessioned2023-09-28T14:03:48Z
dc.date.available2023-09-28T14:03:48Z
dc.date.issued2022en_US
dc.identifier.issn2630-6344
dc.identifier.urihttps://hdl.handle.net/11363/5682
dc.description.abstractCaloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.en_US
dc.language.isoengen_US
dc.publisherMARMARA UNIV, GOZTEPE CAMPUS, KADIKOY, ISTANBUL 34722, TURKEYen_US
dc.relation.isversionof10.29228/jrp.227en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectMetabolic syndromeen_US
dc.subjectBrainen_US
dc.subjectAntioxidanten_US
dc.subjectOxidative stressen_US
dc.subjectExerciseen_US
dc.subjectCaloric restrictionen_US
dc.titleBrain in metabolic syndrome model: The effect of exercises and caloric restrictionen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.departmentDiş Hekimliği Fakültesien_US
dc.authoridhttps://orcid.org/0000-0001-5122-4977en_US
dc.authoridhttps://orcid.org/0000-0001-7444-6193en_US
dc.identifier.volume26en_US
dc.identifier.issue5en_US
dc.identifier.startpage1352en_US
dc.identifier.endpage1362en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.institutionauthorAlev Tüzüner, Burçin


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