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dc.contributor.authorDumlupınar, Berrak
dc.contributor.authorDamar Çelik, Damla
dc.contributor.authorŞeker Karatoprak, Gökçe
dc.contributor.authorSoyoğul Gürer, Ümran
dc.date.accessioned2023-08-12T08:21:07Z
dc.date.available2023-08-12T08:21:07Z
dc.date.issued2022en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.urihttps://hdl.handle.net/11363/5272
dc.description.abstractThis study investigated the bactericidal effects of the essential oil of Pelargonium endlicherianum in combination with four antibiotics commonly used in the treatment of bacterial meningitis (penicillin, ampicillin, ciprofloxacin, and gentamicin) against the meningitis causative pathogens Neisseria meningitidis and Haemophilus influenzae. The phagocytic effects of these combinations were also tested against human leukocyte cells. The bactericidal effect of P. endlicherianum essential oil (PEO) and antibiotic combinations was dynamically detected by time-kill assay. The function of PEO and antibiotic in permeating outer membrane barriers, when used singly or in combination, was analyzed by UV spectrophotometer. The interactions between antibiotic and essential oil were calculated according to the fractional inhibitory concentration (FIC) index. While a synergistic effect of the ciprofloxacin + PEO combination was determined on N. meningitidis (FIC 0.5), an additive effect was observed on H. influenzae (FIC= 1). Combined use of PEO with gentamicin showed a synergistic effect against N. meningitidis and H. influenzae (FIC 0.5). The antimicrobial effect of the penicillin + PEO combination was higher than that of penicillin + PEO used alone. The ampicillin + PEO combination had a synergistic effect on N. meningitidis and an additive effect on H. influenzae. The results of our study showed that the essential oil increases membrane permeability activity and also has phagocytic activity in human leukocyte cells. Combining antibiotics with essential oils that target resistant bacteria may open up new options in combating microbial resistance.en_US
dc.language.isoengen_US
dc.publisherELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDSen_US
dc.relation.isversionof10.1016/j.sajb.2021.10.006en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectPelargonium endlicherianumen_US
dc.subjectN. meningitidesen_US
dc.subjectH. influenzaen_US
dc.subjectAntibioticsen_US
dc.subjectAntibacterial activityen_US
dc.subjectSynergismen_US
dc.titleSynergy between Pelargonium endlicherianum essential oil and conventional antibiotics against Neisseria meningitidis and Haemophilus influenzaeen_US
dc.typearticleen_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.departmentSağlık Bilimleri Fakültesien_US
dc.authoridhttps://orcid.org/0000-0002-0898-3043en_US
dc.authoridhttps://orcid.org/0000-0001-5829-6914en_US
dc.identifier.volume146en_US
dc.identifier.startpage243en_US
dc.identifier.endpage253en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.institutionauthorDumlupınar, Berrak


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