dc.contributor.author | Bayram, Hatice Merve | |
dc.contributor.author | Eren, Fatih | |
dc.contributor.author | Güneş, Fatma Esra | |
dc.date.accessioned | 2023-07-22T11:55:36Z | |
dc.date.available | 2023-07-22T11:55:36Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.issn | 1307-5888 | |
dc.identifier.issn | 2757-7392 | |
dc.identifier.uri | https://hdl.handle.net/11363/5066 | |
dc.description.abstract | Metabolic-associated fatty liver disease (MAFLD) is a public health problem that is increasingly recognized, currently affecting up to a quarter of
the world’s adult population. Although a biopsy is the current gold standard
to diagnose MAFLD, there are potentially serious complications, making
it inadequate. Thus far, noninvasive methods have not been able to determine the stage and the subtype of MAFLD. The development and prognosis of MAFLD are modulated by epigenetic factors, including microRNAs
(miRNAs), which may be potential biomarkers for MAFLD. Polyphenols,
found in many fruits and vegetables, may be useful, as they alter gene expression with epigenetic factors, such as miRNAs. This review presents an
overview of the relationship between polyphenols and miRNAs in MAFLD.
The literature suggests that miRNAs could be used as a diagnostic method
for MAFLD, especially miRNA-122 and miRNA-34a. However, though
it has been demonstrated that polyphenols may contribute to improving
MAFLD, to our knowledge, no study to date has shown the relationship
between polyphenols and miRNAs in MAFLD. The exact mechanisms of
polyphenols on miRNAs in MAFLD remain unclear. Future studies may provide hope for diet therapy for MAFLD patients as well as the development
of polyphenol-related foods or drugs that target miRNAs to treat MAFLD. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | KARE PUBL, Göztepe Mah. Fahrettin Kerim Gökay Caddesi. No: 200/A D:2 Çemenzar - Kadıköy, İSTANBUL 34720, TURKEY | en_US |
dc.relation.isversionof | 10.14744/hf.2021.2021.0037 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Metabolic-associated fatty liver disease | en_US |
dc.subject | microRNA | en_US |
dc.subject | polyphenols | en_US |
dc.title | The relationship between polyphenols and miRNAs: A novel therapeutic strategy for metabolic associated fatty liver disease | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Hepatology Forum | en_US |
dc.department | Sağlık Bilimleri Fakültesi | en_US |
dc.identifier.volume | 2 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 128 | en_US |
dc.identifier.endpage | 136 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.institutionauthor | Bayram, Hatice Merve | |