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High levels of global genome methylation in patients with retinoblastoma

Yazıcı, Hülya; Wu, Hui-Chen; Tığlı, Hülya; Yılmaz, Elif Z.; Kebudi, Rejin; Santella, Regina M. (SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE, 2020)

Retinoblastoma is a tumor of the embryonic neural retina in young children. The DNA methyltransferase 1 (DNMT1) gene has been demonstrated to be transcriptionally activated in cells lacking retinoblastoma 1 (RB1). Thus, ...