dc.contributor.author | Melekoğlu, Abdullah | |
dc.contributor.author | Ceviz, Ayşe Begüm | |
dc.contributor.author | Eronat, Allison Pınar | |
dc.contributor.author | Öztürk, Tülin | |
dc.contributor.author | Pehlevan, Funda | |
dc.contributor.author | Yılmaz Aydoğan, Hülya | |
dc.contributor.author | Öztürk, Oğuz | |
dc.date.accessioned | 2024-03-13T19:10:28Z | |
dc.date.available | 2024-03-13T19:10:28Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.issn | 1300-6045 | |
dc.identifier.issn | 1309-2251 | |
dc.identifier.uri | https://hdl.handle.net/11363/7195 | |
dc.description.abstract | In this study, the cytotoxic and apoptotic effects of three phenolic compounds highly found
in the poplar type propolis; pinostrobin (PS), pinocembrin (PC) and pinobanksin (PB),
were investigated individually and in combination on hormon-positive (MCF-7) and
triple negative (MDA-MB-231) breast cancer cell lines and fibrocystic breast epithelium
(MCF-10A) as control. Assessment of cytotoxicity and apoptosis were performed with
WST-1 and Annexin V-7AAD assays, respectively. All statistical analyses including the
two-way ANOVA and multiple-t-test were performed using GraphPad Prism software.
Individually, PB (P<0.0001), PS (P<0.0001), and PC (P<0.05) demonstrated potent
cytotoxic effects at moderate to high doses and late time intervals on MCF-7. PB and
PS have been found to have a significant proliferative effect at low doses (P<0.0001),
however, this effect disappeared in higher doses in this cell line. Dual combinations
of PB+PC and PB+PS were toxic on MCF-10A, however, dual combination of PS+PC
and the triple combination (PB+PS+PC) showed no cytotoxicity until high doses at late
time intervals (P>0.05). On MCF-7, the triple combination induced cytotoxic/apoptotic
effects even with the 25% dose and 50% dose on MDA-MB-231(p<0.0001). Our findings
clearly showed that different combinations of these phenolic substances can have
synergistic cytotoxic effects and even hormetic effects in non-tumorogenic cells. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | KAFKAS UNIV, VETERINER FAKULTESI DERGISIKAFKAS UNIV, VETERINER FAKULTESI DERGISI, KARS 36040, TURKEY | en_US |
dc.relation.isversionof | 10.9775/kvfd.2023.30187 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Breast cancer cell line | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Pinobanksin | en_US |
dc.subject | Pinocembrin | en_US |
dc.subject | Pinostrobin | en_US |
dc.subject | Propolis | en_US |
dc.title | Synergistic and Dose-Dependent Effects of Pinostrobin, Pinocembrin and Pinobanksin on Different Breast Cancer Cell Lines | en_US |
dc.type | article | en_US |
dc.relation.ispartof | KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI | en_US |
dc.department | Sağlık Hizmetleri Meslek Yüksekokulu | en_US |
dc.authorid | https://orcid.org/0000-0002-5214-292X | en_US |
dc.authorid | https://orcid.org/0000-0002-3635-8421 | en_US |
dc.authorid | https://orcid.org/0000-0002-8095-1759 | en_US |
dc.authorid | https://orcid.org/0000-0001-6910-1131 | en_US |
dc.authorid | https://orcid.org/0000-0003-3906-977X | en_US |
dc.authorid | https://orcid.org/0000-0002-8837-6664 | en_US |
dc.authorid | https://orcid.org/0000-0002-2439-9269 | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 23 | en_US |
dc.identifier.endpage | 30 | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.institutionauthor | Pehlevan, Funda | |