Yanar, KarolinAtayik, Mehmet CanHorozoglu, CemDemirkol, SeydaSimsek, BahadirVerim, AysegulKucukhuseyin, Ozlem2024-09-112024-09-1120230973-14821998-4138https://doi.org/10.4103/jcrt.jcrt_1081_21https://hdl.handle.net/11363/8103Background:Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The present research is conducted to investigate whether specific gene polymorphism of ICAM-1 K469E (rs5498) and plasma redox status could be associated with laryngeal cancer (LC) development. Since there is no clear evidence which investigates the relationship between ICAM-1 polymorphism and ROS-mediated plasma protein oxidation in LC, our study is the first significant contribution for investigating the relationship.Methods:The study covered patients with primary LC and their age-matched healthy control subjects. Evaluation of ICAM-1 K469E (rs5498) gene polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Plasma redox status was assessed with spectrophotometric methods.Results:In the current paper, we found that LC patients with GG genotype had a decreasing trend for the plasma oxidative damage biomarker levels when compared with all allele genotypes (AA and AG).Conclusion:We concluded that G allele of the ICAM-1 K469E gene plays a significant role in the optimal regulation of plasma redox homeostasis in patients with LC.eninfo:eu-repo/semantics/openAccessGene polymorphismsintercellular adhesion molecule 1laryngeal canceroxidative stressplasma proteinsArticle1971781178710.4103/jcrt.jcrt_1081_21383762782-s2.0-85181440372WOS:001134479700053Q4