Yılmaz, Enver DemirelÜstündağ, Mehmet FatihGençer, Ali GörkemKıvrak, YükselÜnal, ÖzgeBilici, Mustafa2023-10-032023-10-0320161300-01441303-6165https://hdl.handle.net/11363/5734https://search.trdizin.gov.tr/tr/yayin/detay/248558https://doi.org/Background/aim: We aimed to investigate and compare to healthy controls the variations in the levels of nitric oxide (NO), asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), and L-arginine levels in patients with obsessive-compulsive disorder (OCD). Materials and methods: We enrolled 30 patients with OCD and 30 healthy controls in the study consecutively. Diagnostic interviews of all participants were conducted with the Structured Clinical Interview for Axis I Disorders (SCID-I), and sociodemographic data of the participants were recorded. Patients scoring 10 points or more on the Yale–Brown Obsessive-Compulsive Scale were enrolled in the study. Results: The NO levels of patients with OCD were increased compared to the control group, but the increase was not statistically significant (P > 0.05). However, patients with OCD had significantly lower levels of ADMA, SDMA, and L-arginine compared with the controls (P < 0.001). Conclusion: We found a significant decrease in ADMA, SDMA, and L-arginine as NO inhibitors between the groups, possibly because of an increase in NO. However, the insignificant increase in NO suggests that ADMA, SDMA, and L-arginine play direct and potentially important roles in OCD biology.eninfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 United StatesObsessive-compulsive disorderNitric oxideAsymmetric dimethyl arginineSymmetric dimethyl arginineL-arginineArticle46377578210.3906/sag-1503-100275132552-s2.0-84964034600Q3248558WOS:000374327500028Q3