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dc.contributor.authorÜçüncü, Muhammed Zübeyr
dc.contributor.authorSerilmez, Murat
dc.contributor.authorSarı, Murat
dc.contributor.authorBademler, Süleyman
dc.contributor.authorKarabulut, Senem
dc.date.accessioned2020-06-05T23:24:04Z
dc.date.available2020-06-05T23:24:04Z
dc.date.issued2019en_US
dc.identifier.issn2218-273X
dc.identifier.urihttps://hdl.handle.net/11363/2182
dc.descriptionDocument Information Language:English Accession Number: WOS:000489102800076 PubMed ID: 31505877en_US
dc.description.abstractIn this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), C-C motif chemokine ligand 5 (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma and healthy controls in order to investigate the significance and usability of these potential biomarkers in early diagnosis of colorectal cancer. The study included 70 colorectal carcinoma patients and 40 healthy individuals. The CCR5, CCL5, PDGF, and EphA7 levels were measured using ELISA in blood samples. PDGF-BB, EphA7, CCR5, and CCL5 levels of the patients with colorectal carcinoma were significantly higher compared to the control group (p < 0.001 for each comparison). Our logistic regression analysis (the area under the curve was 0.958) supports the notion that PDGF-BB, EphA7, and CCL5 are potential biomarkers for the diagnosis of colon cancer. The sensitivity, specificity, and positive and negative predictive values were found to be 87.9%, 87.5%, 92.1%, and 81.4%, respectively. To our knowledge, this is the first study that investigates the relationship between colorectal carcinoma and the four biomarkers CCL5, CCR5, PDGF, and EphA7. The significantly elevated levels of all these parameters in the patient group compared to the healthy controls indicate that they can be used for the early diagnosis of colorectal carcinoma.en_US
dc.language.isoengen_US
dc.publisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLANDen_US
dc.relation.isversionof10.3390/biom9090464en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCCL5en_US
dc.subjectCCR5en_US
dc.subjectchemokineen_US
dc.subjectcolorectal carcinomaen_US
dc.subjectcytokineen_US
dc.subjectEphA7en_US
dc.subjectPDGFen_US
dc.subjectCELLSen_US
dc.subjectEXPRESSIONen_US
dc.subjectMICROENVIRONMENTen_US
dc.subjectFIBROBLASTSen_US
dc.subjectPREVENTIONen_US
dc.subjectGROWTHen_US
dc.titleThe Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Canceren_US
dc.typearticleen_US
dc.relation.ispartofBIOMOLECULESen_US
dc.departmentSağlık Bilimleri Yüksekokuluen_US
dc.authoridhttps://orcid.org/0000-0003-4638-1059en_US
dc.authoridhttps://orcid.org/0000-0003-0596-1559en_US
dc.identifier.volume9en_US
dc.identifier.issue9en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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