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dc.contributor.authorİnce, İkbal Agah
dc.contributor.authorÖzcan, Orhan
dc.contributor.authorİlter Akülke, Ayca Zeynep
dc.contributor.authorScully, Erin D.
dc.contributor.authorÖzgen, Arzu
dc.date.accessioned2019-02-04T12:40:24Z
dc.date.available2019-02-04T12:40:24Z
dc.date.issued2018-03-30
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/11363/1112
dc.description.abstractMembers of the family Iridoviridae (iridovirids) are large dsDNA viruses that infect both invertebrate and vertebrate ectotherms and whose symptoms range in severity from minor reductions in host fitness to systemic disease and large-scale mortality. Several characteristics have been useful for classifying iridoviruses; however, novel strains are continuously being discovered and, in many cases, reliable classification has been challenging. Further impeding classification, invertebrate iridoviruses (IIVs) can occasionally infect vertebrates; thus, host range is often not a useful criterion for classification. In this review, we discuss the current classification of iridovirids, focusing on genomic and structural features that distinguish vertebrate and invertebrate iridovirids and viral factors linked to host interactions in IIV6 (Invertebrate iridescent virus 6). In addition, we show for the first time how complete genome sequences of viral isolates can be leveraged to improve classification of new iridovirid isolates and resolve ambiguous relations. Improved classification of the iridoviruses may facilitate the identification of genus-specific virulence factors linked with diverse host phenotypes and host interactions.en_US
dc.language.isoengen_US
dc.publisherVirusesen_US
dc.relation.isversionofhttps://dx.doi.org/10.3390%2Fv10040161en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleInvertebrate Iridoviruses: A Glance over the Last Decadeen_US
dc.typearticleen_US
dc.relation.journalVirusesen_US
dc.contributor.departmentİstanbul Gelişim Üniversitesien_US
dc.identifier.volume10en_US
dc.identifier.issue4en_US
dc.identifier.startpage1en_US
dc.identifier.endpage25en_US
dc.relation.publicationcategoryKategori Yoken_US


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