Yazar "Oğuztüzün, Serpil" için listeleme
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Comparison of the tissue expressions of glutathione S transferase isoenzymes among patients with morphea and healthy controls: A preliminary study
Uzunçakmak, Tuğba Kevser; Koska, Mahmut Can; Özkanlı, Şeyma; Kaya Koçdoğan, Arzu; Oğuztüzün, Serpil; Karadağ, Ayşe Serap; Akdeniz, Necmettin; Wollina, Uwe (WILEY-HINDAWI, ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON WIT 5HE, ENGLAND, 2020)Morphea is an inflammatory connective tissue disorder, which is characterized by sclerosis in skin and subcutaneous tissues with a chronic progress. The oxidative stress in pathogenesis of sclerosing diseases was proposed ... -
Expression of CYP and GST in human normal and colon tumor tissues
Buluş, Hakan; Oğuztüzün, Serpil; Güler Şimşek, Gülçin; Kılıç, Murat; Ada, Ahmet Oğuz; Göl, Saliha; Kaya Koçdoğan, Arzu; Kaygın, Pınar; Bozer, Büşra; İşcan, Mümtaz (TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, 2019)We investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1, and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 in colon tumor and surrounding normal colon ... -
Expressions of CYP and GST Isoenzymes in Human Gastric Tumor and Non-Tumor Tissues
Güler Şimşek, Gülçin; Oğuztüzün, Serpil; Bozer, Büşra; Kılıç, Murat; Kaya Koçdoğan, Arzu; Kaygın, Pınar; Gürbüz, Nurdan; Buluş, Hakan (Uluslararası Hematoloji Onkoloji Dergisi, 2018)In this study we investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1 and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 isoenzymes in gastric tumor and ... -
GSTM1, GSTP1, p53 as some probable predictors of prognosis in primary and metastatic epithelial ovarian cancer
Özer, Gizem; Kaygın, Pınar; Dirican, Onur; Oğuztüzün, Serpil; Yılmaz Sarıaltın, Sezen; Şimşek, Gülçin Güler; Erdem, Ayşegül; Kılıç, Murat; Çoban, Tülay (Prusa Medikal Yayıncılık Limited Şirketi, 2023)Objectives: Ovarian carcinomas are responsible for the death of more women than all other gynecologic malignancies in the Western world. Ovarian carcinomas are detected in an advanced stage of the disease in approximately ... -
Immunohistochemical approach to obesity disease in terms of expression levels of glutathione s-transferase (sigma, zeta, theta) isozymes
Davudov, Mahammad; Buluş, Hakan; Dirican, Onur; Kaygın, Pınar; Şimşek, Gülçin Güler; Yılmaz Sarıaltın, Sezen; Gürbüz, Fatıma Nurdan; Oğuztüzün, Serpil (Prusa Medikal Yayıncılık Limited Şirketi, 2023)Objectives: Obesity is a complex multifactorial disease with recently increasing prevalence and incidence. Several studies have been conducted to explain the ethiology, pathophysiology, epidemiology, molecular and genetic ... -
Immunohistochemical Evaluation of Apoptosis and Multidrug Resistance- Related Markers in Gallbladder Dysplasia and Carcinoma
Başak, Kayhan; Demir, Derya; Kaya Koçdoğan, Arzu; Oğuztüzün, Serpil (Kartal Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi, 2022)Objective: The search for treatment success in gallbladder carcinomas, which is one of the tumors with the most aggressive course, poor prognosis, and tendency to show resistance to treatment, continues today. Treatments ... -
MCF-7 İnsan Meme Kanseri Hücre Soyunda Doksorubisin Öncesi ve Sonrası GST İzozimlerinin, İlaç Dirençlilik Proteinlerinin ve Apoptotik Etkisinin Araştırılması
Kaya Koçdoğan, Arzu; Oğuztüzün, Serpil; Güler Şimşek, Gülçin; Türk, Mustafa (İstanbul Gelişim Üniversitesi Yayınları / Istanbul Gelisim University Press, 2020)Amaç: Kanser hastalığının tedavisinde karşılaşılan klinik sorunlardan biri hastalara uygulanan kemoterapiye karşı tümör hücrelerinin geliştirdiği dirençtir. Tümör hücrelerinin ilaçlara karşı gösterdiği direncin asıl ... -
Unveiling the etiological impact of GST-M1, GST-T1, and P53 genotypic variations on brain carcinogenesis
Dirican, Onur; Kaygın, Pınar; Oğuztüzün, Serpil; Husseini, Abbas Ali; Yılmaz Sarıaltın, Sezen; Yılmaz, Can; Ünlü, Nihan; İzci, Yusuf (SPRINGERVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2024)Background Functional variants of glutathione-S-transferase (GST)-M1, GST-T1, p53 might modulate brain cancer risk by altering the rate of metabolism and clearance of carcinogens from the brain tissue. In this study, the ...